Transient, inhaled gene therapy with gamma interferon mitigates pathology induced by host response in a mouse model of tuberculosis

Transient transfection of the respiratory mucosa of mice infected with Mycobacterium tuberculosis (Mtb) with gamma interferon (IFN-γ) promises benefits in disease therapy. We investigated preclinical efficacy of a dry powder inhalation (DPI) as a stand-alone versus adjunct to oral anti-tuberculosis...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2022-05, Vol.134, p.102198-102198, Article 102198
Hauptverfasser:	Bharti, Reena, Roy, Trisha, Verma, Sonia, Reddy, D.V. Siva, Shafi, Hasham, Verma, Khushboo, Raman, Sunil K., Pal, Sampita, Azmi, Lubna, Singh, Amit K., Ray, Lipika, Mugale, Madhav N., Misra, Amit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Antitubercular Agents - therapeutic use Chemotherapy Disease Models, Animal Drug dosages Drugs Gamma interferon Gene therapy Genetic Therapy Histopathology Host directed therapy Inhalation Interferon Interferon-gamma - genetics Lung - microbiology Lungs Mice Mycobacterium tuberculosis Oral administration Pathology Pulmonary tuberculosis Respiration Spleen Statistical analysis Transfection Transient transfection Tuberculosis Tuberculosis - drug therapy Tuberculosis - microbiology γ-Interferon
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