Novel naltrexone hydrochloride nanovaccine based on chitosan nanoparticles promotes induction of Th1 and Th17 immune responses resulting in protection against Toxoplasma gondii tachyzoites in a mouse model

This study was aimed to encapsulate and construct the Toxoplasma gondii surface antigen (SAG1) and naltrexone hydrochloride (NLT-HCL) as an adjuvant within chitosan nanoparticles (CS-NPs) to develop efficacious vaccine against T. gondii. Seven groups of BALB/c mice were immunized with SAG1, chitosan...

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Veröffentlicht in:	International journal of biological macromolecules 2022-05, Vol.208, p.962-972
Hauptverfasser:	Khorshidvand, Zohreh, Khosravi, Afra, Mahboobian, Mohammad Mehdi, Larki-Harchegani, Amir, Fallah, Mohammad, Maghsood, Amir Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Animals Antigens, Protozoan Chitosan Disease Models, Animal Immunity, Humoral Interleukin-17 Interleukin-4 Mice Mice, Inbred BALB C Naltrexone Nanoparticles Protozoan Proteins Protozoan Vaccines Recombinant Proteins SAG1 Th1 Cells Th17 Cells Toxoplasma Toxoplasma gondii
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