Scyphocephalione A isolated from the stem bark of Scyphocephalium ochocoa (Myristicaceae) attenuate acute and chronic pain through the antiinflammatory activity
In the treatment of cancer, patients that receive anti-cancer drugs such as Vincristine develop peripheral neuropathic pain. Scyphocephalione A is a new bioactive compound isolated from Scyphocephalium ochocoa (Myristicaceae), a medicinal plant traditionally used in African countries. Recently, an i...
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| Veröffentlicht in: | Inflammopharmacology 2022-06, Vol.30 (3), p.991-1003 |
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| creator | Mbiantcha, Marius Feuya Tchouya, Raymond Guy Nana Yousseu, William Atsamo, Donatien Albert Foundikou, Hibrahim Lebibi, Jacques Zemo, Franklin Gamo |
| description | In the treatment of cancer, patients that receive anti-cancer drugs such as Vincristine develop peripheral neuropathic pain. Scyphocephalione A is a new bioactive compound isolated from
Scyphocephalium ochocoa
(Myristicaceae), a medicinal plant traditionally used in African countries. Recently, an in vitro study has shown its anti-inflammatory and cytotoxic activities on MCF-7 cell line of mammary carcinoma. The purpose of the present study was to assess the in vitro anti-inflammatory and in vivo anti-nociceptive activities of Scyphocephalione A. In vitro tests were carried out on cyclooxygenase and 5-lipoxygenase activities, and on protein denaturation; while in vivo tests were performed on acute and chronic pain models. It was noticed that Scyphocephalione A (1000 µg/ml), inhibits proteins denaturation, cyclooxygenase and 5-lipoxygenase activities respectively by 74.21%, 75.80% and 64.43%. The dose 50 mg/kg of Scyphocephalione A, inhibits acetic acid (63.43%,
p
|
| doi_str_mv | 10.1007/s10787-022-00966-4 |
| format | Article |
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Scyphocephalium ochocoa
(Myristicaceae), a medicinal plant traditionally used in African countries. Recently, an in vitro study has shown its anti-inflammatory and cytotoxic activities on MCF-7 cell line of mammary carcinoma. The purpose of the present study was to assess the in vitro anti-inflammatory and in vivo anti-nociceptive activities of Scyphocephalione A. In vitro tests were carried out on cyclooxygenase and 5-lipoxygenase activities, and on protein denaturation; while in vivo tests were performed on acute and chronic pain models. It was noticed that Scyphocephalione A (1000 µg/ml), inhibits proteins denaturation, cyclooxygenase and 5-lipoxygenase activities respectively by 74.21%, 75.80% and 64.43%. The dose 50 mg/kg of Scyphocephalione A, inhibits acetic acid (63.43%,
p
< 0.001) and formalin (42.12%,
p
< 0.001) within first phase and 67.53% (
p
< 0.001) within second phase)-induced pains. At the same dose, Scyphocephalione A significantly inhibited mechanical and heat hyperalgesia, as well as cold allodynia induced by vincristine. In addition, the compound restored haematological, biochemical and oxidative stress parameters which were altered following Vincristine administration. These results suggest that Scyphocephalione A is endowed with anti-inflammatory potential and antinociceptive properties. Therefore, Scyphocephalione A can be classified as a promising molecule for the management of peripheral neuropathic pain triggered by anti-cancer drug.
Graphical abstract</description><identifier>ISSN: 0925-4692</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-022-00966-4</identifier><identifier>PMID: 35347522</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Analgesics - therapeutic use ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Antineoplastic Agents - therapeutic use ; Arachidonate 5-Lipoxygenase ; Biomedical and Life Sciences ; Biomedicine ; Chronic Pain - drug therapy ; Cyclooxygenase 2 - metabolism ; Dermatology ; Disease Models, Animal ; Gastroenterology ; Humans ; Hyperalgesia - drug therapy ; Immunology ; Myristicaceae - metabolism ; Neuralgia - drug therapy ; Original Article ; Pharmacology/Toxicology ; Plant Bark ; Rheumatology ; Vincristine</subject><ispartof>Inflammopharmacology, 2022-06, Vol.30 (3), p.991-1003</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-4bab3f37e107c760a6b4cd76c497406d32e1c0741536eeea2430b401932e3b1d3</citedby><cites>FETCH-LOGICAL-c277t-4bab3f37e107c760a6b4cd76c497406d32e1c0741536eeea2430b401932e3b1d3</cites><orcidid>0000-0001-8586-6150</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10787-022-00966-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10787-022-00966-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35347522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mbiantcha, Marius</creatorcontrib><creatorcontrib>Feuya Tchouya, Raymond Guy</creatorcontrib><creatorcontrib>Nana Yousseu, William</creatorcontrib><creatorcontrib>Atsamo, Donatien Albert</creatorcontrib><creatorcontrib>Foundikou, Hibrahim</creatorcontrib><creatorcontrib>Lebibi, Jacques</creatorcontrib><creatorcontrib>Zemo, Franklin Gamo</creatorcontrib><title>Scyphocephalione A isolated from the stem bark of Scyphocephalium ochocoa (Myristicaceae) attenuate acute and chronic pain through the antiinflammatory activity</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description>In the treatment of cancer, patients that receive anti-cancer drugs such as Vincristine develop peripheral neuropathic pain. Scyphocephalione A is a new bioactive compound isolated from
Scyphocephalium ochocoa
(Myristicaceae), a medicinal plant traditionally used in African countries. Recently, an in vitro study has shown its anti-inflammatory and cytotoxic activities on MCF-7 cell line of mammary carcinoma. The purpose of the present study was to assess the in vitro anti-inflammatory and in vivo anti-nociceptive activities of Scyphocephalione A. In vitro tests were carried out on cyclooxygenase and 5-lipoxygenase activities, and on protein denaturation; while in vivo tests were performed on acute and chronic pain models. It was noticed that Scyphocephalione A (1000 µg/ml), inhibits proteins denaturation, cyclooxygenase and 5-lipoxygenase activities respectively by 74.21%, 75.80% and 64.43%. The dose 50 mg/kg of Scyphocephalione A, inhibits acetic acid (63.43%,
p
< 0.001) and formalin (42.12%,
p
< 0.001) within first phase and 67.53% (
p
< 0.001) within second phase)-induced pains. At the same dose, Scyphocephalione A significantly inhibited mechanical and heat hyperalgesia, as well as cold allodynia induced by vincristine. In addition, the compound restored haematological, biochemical and oxidative stress parameters which were altered following Vincristine administration. These results suggest that Scyphocephalione A is endowed with anti-inflammatory potential and antinociceptive properties. Therefore, Scyphocephalione A can be classified as a promising molecule for the management of peripheral neuropathic pain triggered by anti-cancer drug.
Graphical abstract</description><subject>Allergology</subject><subject>Analgesics - therapeutic use</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Arachidonate 5-Lipoxygenase</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chronic Pain - drug therapy</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Dermatology</subject><subject>Disease Models, Animal</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Hyperalgesia - drug therapy</subject><subject>Immunology</subject><subject>Myristicaceae - metabolism</subject><subject>Neuralgia - drug therapy</subject><subject>Original Article</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Bark</subject><subject>Rheumatology</subject><subject>Vincristine</subject><issn>0925-4692</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu3SAURVHVqrlJ-wMdVAzTgZtjwHA9jKL0IaXKoMkYYXwck9rgAo7kv-mnluSmlTrpBITO3gvBIuRdDR9rAHWWalB7VQFjFUArZSVekF3dyH3VSNi_JDtoWVMJ2bIjcpzSPQBIJdvX5Ig3XKiGsR359d1uyxgsLqOZXPBIz6lLYTIZezrEMNM8Ik0ZZ9qZ-IOGgf7TWGcabDkFQ0-_bdGl7KyxaPADNTmjXwuIGrs-rr6ndozBO0sX43whx7DejU83GJ-d88Nk5tnkELfSye7B5e0NeTWYKeHb5_2E3H66vLn4Ul1df_56cX5VWaZUrkRnOj5wheVPrJJgZCdsr6QVrRIge86wtqBE3XCJiIYJDp2Aui0D3tU9PyGnB-4Sw88VU9azSxanyXgMa9JMCtEK0XBWouwQtTGkFHHQS3SziZuuQT-a0QczupjRT2a0KKX3z_y1m7H_W_mjogT4IZDKyN9h1Pdhjb68-X_Y39UXnMg</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Mbiantcha, Marius</creator><creator>Feuya Tchouya, Raymond Guy</creator><creator>Nana Yousseu, William</creator><creator>Atsamo, Donatien Albert</creator><creator>Foundikou, Hibrahim</creator><creator>Lebibi, Jacques</creator><creator>Zemo, Franklin Gamo</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8586-6150</orcidid></search><sort><creationdate>20220601</creationdate><title>Scyphocephalione A isolated from the stem bark of Scyphocephalium ochocoa (Myristicaceae) attenuate acute and chronic pain through the antiinflammatory activity</title><author>Mbiantcha, Marius ; Feuya Tchouya, Raymond Guy ; Nana Yousseu, William ; Atsamo, Donatien Albert ; Foundikou, Hibrahim ; Lebibi, Jacques ; Zemo, Franklin Gamo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-4bab3f37e107c760a6b4cd76c497406d32e1c0741536eeea2430b401932e3b1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Allergology</topic><topic>Analgesics - therapeutic use</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Arachidonate 5-Lipoxygenase</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chronic Pain - drug therapy</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Dermatology</topic><topic>Disease Models, Animal</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Hyperalgesia - drug therapy</topic><topic>Immunology</topic><topic>Myristicaceae - metabolism</topic><topic>Neuralgia - drug therapy</topic><topic>Original Article</topic><topic>Pharmacology/Toxicology</topic><topic>Plant Bark</topic><topic>Rheumatology</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mbiantcha, Marius</creatorcontrib><creatorcontrib>Feuya Tchouya, Raymond Guy</creatorcontrib><creatorcontrib>Nana Yousseu, William</creatorcontrib><creatorcontrib>Atsamo, Donatien Albert</creatorcontrib><creatorcontrib>Foundikou, Hibrahim</creatorcontrib><creatorcontrib>Lebibi, Jacques</creatorcontrib><creatorcontrib>Zemo, Franklin Gamo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mbiantcha, Marius</au><au>Feuya Tchouya, Raymond Guy</au><au>Nana Yousseu, William</au><au>Atsamo, Donatien Albert</au><au>Foundikou, Hibrahim</au><au>Lebibi, Jacques</au><au>Zemo, Franklin Gamo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scyphocephalione A isolated from the stem bark of Scyphocephalium ochocoa (Myristicaceae) attenuate acute and chronic pain through the antiinflammatory activity</atitle><jtitle>Inflammopharmacology</jtitle><stitle>Inflammopharmacol</stitle><addtitle>Inflammopharmacology</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>30</volume><issue>3</issue><spage>991</spage><epage>1003</epage><pages>991-1003</pages><issn>0925-4692</issn><eissn>1568-5608</eissn><abstract>In the treatment of cancer, patients that receive anti-cancer drugs such as Vincristine develop peripheral neuropathic pain. Scyphocephalione A is a new bioactive compound isolated from
Scyphocephalium ochocoa
(Myristicaceae), a medicinal plant traditionally used in African countries. Recently, an in vitro study has shown its anti-inflammatory and cytotoxic activities on MCF-7 cell line of mammary carcinoma. The purpose of the present study was to assess the in vitro anti-inflammatory and in vivo anti-nociceptive activities of Scyphocephalione A. In vitro tests were carried out on cyclooxygenase and 5-lipoxygenase activities, and on protein denaturation; while in vivo tests were performed on acute and chronic pain models. It was noticed that Scyphocephalione A (1000 µg/ml), inhibits proteins denaturation, cyclooxygenase and 5-lipoxygenase activities respectively by 74.21%, 75.80% and 64.43%. The dose 50 mg/kg of Scyphocephalione A, inhibits acetic acid (63.43%,
p
< 0.001) and formalin (42.12%,
p
< 0.001) within first phase and 67.53% (
p
< 0.001) within second phase)-induced pains. At the same dose, Scyphocephalione A significantly inhibited mechanical and heat hyperalgesia, as well as cold allodynia induced by vincristine. In addition, the compound restored haematological, biochemical and oxidative stress parameters which were altered following Vincristine administration. These results suggest that Scyphocephalione A is endowed with anti-inflammatory potential and antinociceptive properties. Therefore, Scyphocephalione A can be classified as a promising molecule for the management of peripheral neuropathic pain triggered by anti-cancer drug.
Graphical abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35347522</pmid><doi>10.1007/s10787-022-00966-4</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8586-6150</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0925-4692 |
| ispartof | Inflammopharmacology, 2022-06, Vol.30 (3), p.991-1003 |
| issn | 0925-4692 1568-5608 |
| language | eng |
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| subjects | Allergology Analgesics - therapeutic use Animals Anti-Inflammatory Agents - therapeutic use Antineoplastic Agents - therapeutic use Arachidonate 5-Lipoxygenase Biomedical and Life Sciences Biomedicine Chronic Pain - drug therapy Cyclooxygenase 2 - metabolism Dermatology Disease Models, Animal Gastroenterology Humans Hyperalgesia - drug therapy Immunology Myristicaceae - metabolism Neuralgia - drug therapy Original Article Pharmacology/Toxicology Plant Bark Rheumatology Vincristine |
| title | Scyphocephalione A isolated from the stem bark of Scyphocephalium ochocoa (Myristicaceae) attenuate acute and chronic pain through the antiinflammatory activity |
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