Production of human spinal-cord organoids recapitulating neural-tube morphogenesis

Human spinal-cord-like tissues induced from human pluripotent stem cells are typically insufficiently mature and do not mimic the morphological features of neurulation. Here, we report a three-dimensional culture system and protocol for the production of human spinal-cord-like organoids (hSCOs) reca...

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Veröffentlicht in:	Nature biomedical engineering 2022-04, Vol.6 (4), p.435-448
Hauptverfasser:	Lee, Ju-Hyun, Shin, Hyogeun, Shaker, Mohammed R., Kim, Hyun Jung, Park, Si-Hyung, Kim, June Hoan, Lee, Namwon, Kang, Minjin, Cho, Subin, Kwak, Tae Hwan, Kim, Jong Woon, Song, Mi-Ryoung, Kwon, Seung-Hae, Han, Dong Wook, Lee, Sanghyuk, Choi, Se-Young, Rhyu, Im Joo, Kim, Hyun, Geum, Dongho, Cho, Il-Joo, Sun, Woong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/1660 631/1647/2163 631/378/1689/2608 631/532/2182 631/61/2320 Antiepileptic agents Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Cell culture Defects Differentiation (biology) Drug screening Drugs Glial cells Humans Morphogenesis Morphogenesis - physiology Neural Tube Defects Neuronal-glial interactions Neurulation - physiology Organoids Pluripotency Spinal Cord Stem cells
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