Downregulation of Kcnq1ot1 attenuates β-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis

Aim To examine the effect of lncRNA Kcnq1ot1 on pancreatic β cells in the development of diabetes. Methods The expression levels of Kcnq1ot1 were detected in the islets of diabetes mouse models and the serum of patients with type 2 diabetes by qRT-PCR. CCK8, Ki67 staining, immunohistochemical analys...

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Veröffentlicht in:	Acta diabetologica 2022-07, Vol.59 (7), p.885-899
Hauptverfasser:	Li, Yanli, Chen, Yalan, Liu, Ziyu, Lin, Beisi, Deng, Xiaoyi, Xiao, Qiwen, Chen, Zhishan, Ye, Huiyu, Chen, Danrui, Su, Yanna, Li, Wangen, Xu, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Beta cells Bioinformatics Cell growth Cell proliferation Diabetes Diabetes mellitus (non-insulin dependent) Glucose Glucose tolerance Immunofluorescence Insulin Insulin secretion Internal Medicine KCNQ1OT1 protein Medicine Medicine & Public Health Metabolic Diseases Original Article Patients Potassium channels (voltage-gated) Transcription factors
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