Formulation and optimization of silymarin-encapsulated binary micelles for enhanced amyloid disaggregation activity

Silymarin (SLY) is a natural hydrophobic polyphenol that possesses antioxidant and amyloid fibril (Aβ 1-42 ) inhibition activity, but its activity is hindered due to low aqueous solubility. In this study, SLY is encapsulated in binary micelle (SLY-BM) that has been utilized to enhance the Aβ 1-42 fi...

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Veröffentlicht in:	Drug development and industrial pharmacy 2021-11, Vol.47 (11), p.1775-1785
Hauptverfasser:	Singh, Ajit, Ujjwal, Rewati Raman, Kumar, Ashish, Verma, Rahul K., Shukla, Rahul
Format:	Artikel
Sprache:	eng
Schlagworte:	1-42 Antioxidant binary micelle Box-Behnken design disaggregation Silymarin
Online-Zugang:	Volltext
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