Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment

GABPB1, known as nuclear respiratory factor 2 (Nrf2), activates the mitochondrial genes that are responsible for antioxidant action and detoxification. Two single nucleotide polymorphisms (SNPs) of GABPB1, such as rs7181866 and rs8031031, were reported to be associated with the prevention of the inc...

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Veröffentlicht in:	Toxicology and industrial health 2022-04, Vol.38 (4), p.193-200
Hauptverfasser:	Xu, Pei, Xu, Xingjie, Liu, Jun, Hu, Huajun, Shen, Huajiang, Chen, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Antioxidants Case-Control Studies Detoxification Environmental degradation Environmental factors Female GA-binding protein GA-Binding Protein Transcription Factor - genetics Gene Frequency Genetic Predisposition to Disease Genotype Health risks Humans Leukocytes, Mononuclear Male Mitochondria Mutation Nucleotides Occupational Exposure Peripheral blood mononuclear cells Physical factors Polymorphism, Single Nucleotide Regression analysis Single-nucleotide polymorphism
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