Influence of mutation in the regulatory domain of α-isopropylmalate synthase from Saccharomyces cerevisiae on its activity and feedback inhibition

Isoamyl alcohol (i-AmOH) is produced from α-ketoisocaproate in the l-leucine biosynthetic pathway in yeast and controlled by the negative feedback regulation of α-isopropylmalate synthase (IPMS), which senses the accumulation of l-leucine. It is known that i-AmOH production increases when mutations...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2022-05, Vol.86 (6), p.755-762
Hauptverfasser:	Takagi, Hironobu, Yamamoto, Kazuki, Matsuo, Yoshifumi, Furuie, Miki, Kasayuki, Yasuha, Ohtani, Rina, Shiotani, Mizuki, Hasegawa, Tetsuya, Ohnishi, Toru, Ohashi, Masataka, Johzuka, Katsuki, Kurata, Atsushi, Uegaki, Koichi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!