Construction of a Reduction‐responsive DNA Microsphere using a Reduction‐cleavable Spacer based on a Nitrobenzene Scaffold

Here, we describe the design and synthesis of a new reduction‐cleavable spacer (RCS) based on a nitrobenzene scaffold for constructing reduction‐responsive oligonucleotides according to standard phosphoramidite chemistry. In addition, we demonstrate that the introduction of the RCS in the middle of...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2022-05, Vol.17 (10), p.e202200142-n/a
Hauptverfasser:	Higashi, Sayuri L., Isogami, Ayaka, Takahashi, Junko, Shibata, Aya, Hirosawa, Koichiro M., Suzuki, Kenichi G. N., Sawada, Shunsuke, Tsukiji, Shinya, Matsuura, Kazunori, Ikeda, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry cleavage reaction DNA DNA structures Microspheres Nitrobenzene Nitrobenzenes Oligonucleotides Reduction Scaffolds self-assembly
Online-Zugang:	Volltext
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