Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance their efficacy and to reduce their adverse effects. These efforts include the development of nanomedicines as they can selectively penetrate through tumor blood vessels through the enhanced permeability and reten...

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Veröffentlicht in:	Journal of controlled release 2022-05, Vol.345, p.512-536
Hauptverfasser:	Ikeda-Imafuku, Mayumi, Wang, Lily Li-Wen, Rodrigues, Danika, Shaha, Suyog, Zhao, Zongmin, Mitragotri, Samir
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Clinical trials Drug Delivery Systems EPR effect Humans Nanomedicine Nanoparticles Neoplasms - drug therapy Permeability Tumor Microenvironment
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