Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats

The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB-mediated inflammation, were investigated. Male Wistar rats subcutaneously administered with multiple doses of 1.5 mg/kg roteno...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurotoxicology (Park Forest South) 2022-05, Vol.90, p.158-171
Hauptverfasser:	Josiah, Sunday Solomon, Famusiwa, Courage Dele, Crown, Olamide Olajusi, Lawal, Akeem O., Olaleye, Mary Tolulope, Akindahunsi, Afolabi Akintunde, Akinmoladun, Afolabi Clement
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Attenuation Basal ganglia Brain diseases Catechin Catechin - adverse effects Central nervous system diseases Depletion Dopamine Dopamine - metabolism Flavonoids Gene expression Genes Genes, p53 IL-1β Inflammation Inflammation - metabolism Male Males Metabolism Modulation Movement disorders Neostriatum Neurodegenerative diseases Neuroprotection Neuroprotective Agents - therapeutic use Neurotoxicity Neurotransmitters NF-kappa B - metabolism NF-κB and p53 gene expression NF-κB protein Optimization Oxidative Stress p53 Protein Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Quercetin Quercetin - pharmacology Rats Rats, Wistar Rodents Rotenone Rotenone - toxicity Toxicity Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!