Activation of 5-Hydroxytryptamine 4 Receptor Improves Colonic Barrier Function by Triggering Mucin 2 Production in a Mouse Model of Type 1 Diabetes

Diabetes leads to intestinal barrier dysfunction. 5-Hydroxytryptamine 4 receptor (5-HT4R) is distributed in the colonic mucosa, but little is known about the role of its activation in diabetes-evoked colonic barrier dysfunction. This study investigates whether activation of 5-HT4Rs on goblet cells (...

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Veröffentlicht in:	The American journal of pathology 2022-06, Vol.192 (6), p.876-886
Hauptverfasser:	Han, Changhao, Geng, Qinghua, Qin, Jingjing, Li, Yulin, Yu, Huarong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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