Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination
Abstract We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 3...
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| Veröffentlicht in: | The Journal of infectious diseases 2022-05, Vol.225 (10), p.1688-1693 |
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| creator | Rieke, Gereon J van Bremen, Kathrin Bischoff, Jenny ToVinh, Michael Monin, Malte B Schlabe, Stefan Raabe, Jan Kaiser, Kim M Finnemann, Claudia Odainic, Alexandru Kudaliyanage, Anushka Latz, Eicke Strassburg, Christian P Boesecke, Christoph Schmidt, Susanne V Krämer, Benjamin Rockstroh, Jürgen K Nattermann, Jacob |
| description | Abstract
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
Analyzing the ability of SARS-CoV-2 spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) we found antibodies elicited by natural infection to induce a significantly stronger ADCC response compared to those induced by vaccination. |
| doi_str_mv | 10.1093/infdis/jiac060 |
| format | Article |
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We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
Analyzing the ability of SARS-CoV-2 spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) we found antibodies elicited by natural infection to induce a significantly stronger ADCC response compared to those induced by vaccination.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiac060</identifier><identifier>PMID: 35323975</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Antibodies ; Coronaviruses ; COVID-19 ; COVID-19 vaccines ; Cytotoxicity ; Immunization ; Natural killer cells ; Severe acute respiratory syndrome coronavirus 2 ; Vaccination</subject><ispartof>The Journal of infectious diseases, 2022-05, Vol.225 (10), p.1688-1693</ispartof><rights>The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-c567e8bcdbd196928db4d47dae7283895b7b1f8649b467c22732290c05cbb58d3</citedby><cites>FETCH-LOGICAL-c397t-c567e8bcdbd196928db4d47dae7283895b7b1f8649b467c22732290c05cbb58d3</cites><orcidid>0000-0002-7700-2915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35323975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rieke, Gereon J</creatorcontrib><creatorcontrib>van Bremen, Kathrin</creatorcontrib><creatorcontrib>Bischoff, Jenny</creatorcontrib><creatorcontrib>ToVinh, Michael</creatorcontrib><creatorcontrib>Monin, Malte B</creatorcontrib><creatorcontrib>Schlabe, Stefan</creatorcontrib><creatorcontrib>Raabe, Jan</creatorcontrib><creatorcontrib>Kaiser, Kim M</creatorcontrib><creatorcontrib>Finnemann, Claudia</creatorcontrib><creatorcontrib>Odainic, Alexandru</creatorcontrib><creatorcontrib>Kudaliyanage, Anushka</creatorcontrib><creatorcontrib>Latz, Eicke</creatorcontrib><creatorcontrib>Strassburg, Christian P</creatorcontrib><creatorcontrib>Boesecke, Christoph</creatorcontrib><creatorcontrib>Schmidt, Susanne V</creatorcontrib><creatorcontrib>Krämer, Benjamin</creatorcontrib><creatorcontrib>Rockstroh, Jürgen K</creatorcontrib><creatorcontrib>Nattermann, Jacob</creatorcontrib><title>Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
Analyzing the ability of SARS-CoV-2 spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) we found antibodies elicited by natural infection to induce a significantly stronger ADCC response compared to those induced by vaccination.</description><subject>Antibodies</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 vaccines</subject><subject>Cytotoxicity</subject><subject>Immunization</subject><subject>Natural killer cells</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqF0btuFDEUBmALgcgSaCnRSDSkcOLLjC_laCGwIgFEQtqRbwNezdob2yOxL8Lz4mU3FDRUbj7_Ouf8ALzE6BwjSS98GK3PF2uvDGLoEVjgjnLIGKaPwQIhQiAWUp6AZzmvEUItZfwpOKEdJVTybgF-fVJlTmpqPvppcqlZummC1856VZxt-lC8jnYH37qtC9aF8gfMk6pyV2KJP73xZdf035UPuTQ3_dcbuIx3kDT9WGreQ_wqjM4UH0Ozys11TK75Ess-7_aHCkd7p4zxQe3Vc_BkVFN2L47vKfh2-e52-QFefX6_WvZX0NTxCzQd405oY7XFkkkirG5ty61ynAgqZKe5xqNgrdQt44YQTgmRyKDOaN0JS0_Bm0PuNsX72eUybHw2dUUVXJzzQFhLhBS0JZW-_oeu45xCna4q3gmG67WrOj8ok2LOyY3DNvmNSrsBo2Hf2HBobDg2Vj-8OsbOeuPsX_5QUQVnBxDn7f_CfgMSv6Ja</recordid><startdate>20220516</startdate><enddate>20220516</enddate><creator>Rieke, Gereon J</creator><creator>van Bremen, Kathrin</creator><creator>Bischoff, Jenny</creator><creator>ToVinh, Michael</creator><creator>Monin, Malte B</creator><creator>Schlabe, Stefan</creator><creator>Raabe, Jan</creator><creator>Kaiser, Kim M</creator><creator>Finnemann, Claudia</creator><creator>Odainic, Alexandru</creator><creator>Kudaliyanage, Anushka</creator><creator>Latz, Eicke</creator><creator>Strassburg, Christian P</creator><creator>Boesecke, Christoph</creator><creator>Schmidt, Susanne V</creator><creator>Krämer, Benjamin</creator><creator>Rockstroh, Jürgen K</creator><creator>Nattermann, Jacob</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7700-2915</orcidid></search><sort><creationdate>20220516</creationdate><title>Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination</title><author>Rieke, Gereon J ; 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We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
Analyzing the ability of SARS-CoV-2 spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) we found antibodies elicited by natural infection to induce a significantly stronger ADCC response compared to those induced by vaccination.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>35323975</pmid><doi>10.1093/infdis/jiac060</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7700-2915</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Antibodies Coronaviruses COVID-19 COVID-19 vaccines Cytotoxicity Immunization Natural killer cells Severe acute respiratory syndrome coronavirus 2 Vaccination |
| title | Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination |
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