Nanocrystal solid dispersion of fuzapladib free acid with improved oral bioavailability

This study aimed to develop an oral nanocrystal solid dispersion (nCSD) of fuzapladib (FZP) with enhanced absorbability for the treatment of acute pancreatitis (AP). The hydration properties of crystalline FZP free acid (crystalline FZP) and FZP sodium salt (FZP/Na) were assessed to select a stable...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2022-06, Vol.43 (3), p.89-97
Hauptverfasser:	Yamada, Kohei, Hayashi, Yuto, Sasaki, Kenta, Higuchi, Koji, Shindo, Takeshi, Shikama, Hiroshi, Sato, Hideyuki, Onoue, Satomi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Cellulose Dissolution fuzapladib hydration property multi‐inlet vortex mixer nanocrystal solid dispersion Nanocrystals Oral administration oral bioavailability Pancreatitis Pharmacokinetics Water activity
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