Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I–III colorectal cancer: a retrospective cohort study
There are no ideal biomarkers including the TNM stage that can accurately predict the recurrence of colorectal cancer (CRC) and the benefit of chemotherapy for stage II patients. Here, 451 CRC patients were divided into three groups according to preoperative levels of prothrombin time (PT) and CEA t...
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| Veröffentlicht in: | Updates in Surgery 2022-06, Vol.74 (3), p.999-1009 |
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| creator | Ma, Lulu Li, Wenya Liu, Ningquan Ding, Zhijie Cai, Jianchun Zhang, Yiyao |
| description | There are no ideal biomarkers including the TNM stage that can accurately predict the recurrence of colorectal cancer (CRC) and the benefit of chemotherapy for stage II patients. Here, 451 CRC patients were divided into three groups according to preoperative levels of prothrombin time (PT) and CEA to analyze the value of these indexes in predicting postoperative recurrence in different TNM stages. Preoperatively elevated levels of PT and CEA were significantly associated with a high 5-year cumulative recurrence rate (CRR) and short recurrence-free survival (RFS). According to PT and CEA levels, the 5-year CRR and RFS differed significantly among the High-risk (PT ≥ 12.65 s and CEA ≥ 10.175 ng/ml), Middle-risk (PT ≥ 12.65 s or CEA ≥ 10.175 ng/ml), and Low-risk (PT |
| doi_str_mv | 10.1007/s13304-022-01268-8 |
| format | Article |
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p
< 0.001). In the same TNM stage, the 5-year CRR of the High-risk group was significantly higher and the RFS was markedly shorter than those in the Low-risk and even those in stage III (
p
< 0.001). In the subgroup of early stage (stage I and II), the 5-year CRR of the High-risk group was significantly higher and the RFS was significantly shorter than those in stage IIIA and IIIB (
p
< 0.001), which is similar to IIIC. In conclusion, preoperatively elevated levels of serum PT and CEA were reliable predictors of postoperative high-risk recurrence in CRC and combined with TNM stage precisely identify postoperative recurrence CRC patients in stage I–III and the benefit of adjuvant chemotherapy for patients with stage II CRC.</description><identifier>ISSN: 2038-131X</identifier><identifier>EISSN: 2038-3312</identifier><identifier>DOI: 10.1007/s13304-022-01268-8</identifier><identifier>PMID: 35322387</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biological markers ; Blood ; Cancer ; Care and treatment ; Chemotherapy ; Colorectal cancer ; Diseases ; Medical examination ; Medicine ; Medicine & Public Health ; Oncology, Experimental ; Original Article ; Prognosis ; Prothrombin ; Relapse ; Surgery ; Thrombin</subject><ispartof>Updates in Surgery, 2022-06, Vol.74 (3), p.999-1009</ispartof><rights>Italian Society of Surgery (SIC) 2022</rights><rights>2022. Italian Society of Surgery (SIC).</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-5b467ace44fde3ef49e6bca6896dffb89fec1bf8f34fef6e4e21c312fecf2b3c3</citedby><cites>FETCH-LOGICAL-c344t-5b467ace44fde3ef49e6bca6896dffb89fec1bf8f34fef6e4e21c312fecf2b3c3</cites><orcidid>0000-0003-3189-8450</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13304-022-01268-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13304-022-01268-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35322387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Lulu</creatorcontrib><creatorcontrib>Li, Wenya</creatorcontrib><creatorcontrib>Liu, Ningquan</creatorcontrib><creatorcontrib>Ding, Zhijie</creatorcontrib><creatorcontrib>Cai, Jianchun</creatorcontrib><creatorcontrib>Zhang, Yiyao</creatorcontrib><title>Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I–III colorectal cancer: a retrospective cohort study</title><title>Updates in Surgery</title><addtitle>Updates Surg</addtitle><addtitle>Updates Surg</addtitle><description>There are no ideal biomarkers including the TNM stage that can accurately predict the recurrence of colorectal cancer (CRC) and the benefit of chemotherapy for stage II patients. Here, 451 CRC patients were divided into three groups according to preoperative levels of prothrombin time (PT) and CEA to analyze the value of these indexes in predicting postoperative recurrence in different TNM stages. Preoperatively elevated levels of PT and CEA were significantly associated with a high 5-year cumulative recurrence rate (CRR) and short recurrence-free survival (RFS). According to PT and CEA levels, the 5-year CRR and RFS differed significantly among the High-risk (PT ≥ 12.65 s and CEA ≥ 10.175 ng/ml), Middle-risk (PT ≥ 12.65 s or CEA ≥ 10.175 ng/ml), and Low-risk (PT < 12.65 s and CEA < 10.175 ng/ml) groups (
p
< 0.001). In the same TNM stage, the 5-year CRR of the High-risk group was significantly higher and the RFS was markedly shorter than those in the Low-risk and even those in stage III (
p
< 0.001). In the subgroup of early stage (stage I and II), the 5-year CRR of the High-risk group was significantly higher and the RFS was significantly shorter than those in stage IIIA and IIIB (
p
< 0.001), which is similar to IIIC. In conclusion, preoperatively elevated levels of serum PT and CEA were reliable predictors of postoperative high-risk recurrence in CRC and combined with TNM stage precisely identify postoperative recurrence CRC patients in stage I–III and the benefit of adjuvant chemotherapy for patients with stage II CRC.</description><subject>Biological markers</subject><subject>Blood</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Diseases</subject><subject>Medical examination</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Prothrombin</subject><subject>Relapse</subject><subject>Surgery</subject><subject>Thrombin</subject><issn>2038-131X</issn><issn>2038-3312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9Uc1u1DAQjhCIVqUvwAH5WA4p8U8Th9tqVehKleihSNwsxxnvuiR2sJ2i3ngH3okH6ZMw22w5Ykv2eOb7PtvzFcVbWp3Tqmo-JMp5JcqKsbKirJalfFEcs4rLknPKXh5iyum3o-I0pbsKB2_36-viiF9wxrhsjos_NzHkXQxj5zzJbgRydnP7nmjfk_XliuhEphi2PqTsDIbQO5PdPZDOhVHH7xATsSGSCQFhgqifihHMHCN4A0TbDJHg8bmSAAWCJ3jdhDnwOZGfLu9IynoLZPP46_dmsyEmDAFlsh6I0SgUPxKN7BxDmmB5ggm7EDPy5v7hTfHK6iHB6WE_Kb5-urxdX5XXXz5v1qvr0nAhcnnRibrRBoSwPXCwooW6M7qWbd1b28nWgqGdlZYLC7YGAYwabCemLeu44SfF2aKLXfkxQ8pqdMnAMGgPYU6K1YJJWde8Qej5At3qAZTzNuSoDc4eRmeCB-swv2qqphWMtnsCWwgGP5kiWDVFh01-ULRSe8_V4rlCz9WT50oi6d3hQXM3Qv-P8uwwAvgCSFjyW4jqLszRY5P-J_sXVbe-Ug</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Ma, Lulu</creator><creator>Li, Wenya</creator><creator>Liu, Ningquan</creator><creator>Ding, Zhijie</creator><creator>Cai, Jianchun</creator><creator>Zhang, Yiyao</creator><general>Springer International Publishing</general><general>Springer</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3189-8450</orcidid></search><sort><creationdate>20220601</creationdate><title>Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I–III colorectal cancer: a retrospective cohort study</title><author>Ma, Lulu ; Li, Wenya ; Liu, Ningquan ; Ding, Zhijie ; Cai, Jianchun ; Zhang, Yiyao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-5b467ace44fde3ef49e6bca6896dffb89fec1bf8f34fef6e4e21c312fecf2b3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biological markers</topic><topic>Blood</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Diseases</topic><topic>Medical examination</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Prothrombin</topic><topic>Relapse</topic><topic>Surgery</topic><topic>Thrombin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Lulu</creatorcontrib><creatorcontrib>Li, Wenya</creatorcontrib><creatorcontrib>Liu, Ningquan</creatorcontrib><creatorcontrib>Ding, Zhijie</creatorcontrib><creatorcontrib>Cai, Jianchun</creatorcontrib><creatorcontrib>Zhang, Yiyao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><jtitle>Updates in Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Lulu</au><au>Li, Wenya</au><au>Liu, Ningquan</au><au>Ding, Zhijie</au><au>Cai, Jianchun</au><au>Zhang, Yiyao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I–III colorectal cancer: a retrospective cohort study</atitle><jtitle>Updates in Surgery</jtitle><stitle>Updates Surg</stitle><addtitle>Updates Surg</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>74</volume><issue>3</issue><spage>999</spage><epage>1009</epage><pages>999-1009</pages><issn>2038-131X</issn><eissn>2038-3312</eissn><abstract>There are no ideal biomarkers including the TNM stage that can accurately predict the recurrence of colorectal cancer (CRC) and the benefit of chemotherapy for stage II patients. Here, 451 CRC patients were divided into three groups according to preoperative levels of prothrombin time (PT) and CEA to analyze the value of these indexes in predicting postoperative recurrence in different TNM stages. Preoperatively elevated levels of PT and CEA were significantly associated with a high 5-year cumulative recurrence rate (CRR) and short recurrence-free survival (RFS). According to PT and CEA levels, the 5-year CRR and RFS differed significantly among the High-risk (PT ≥ 12.65 s and CEA ≥ 10.175 ng/ml), Middle-risk (PT ≥ 12.65 s or CEA ≥ 10.175 ng/ml), and Low-risk (PT < 12.65 s and CEA < 10.175 ng/ml) groups (
p
< 0.001). In the same TNM stage, the 5-year CRR of the High-risk group was significantly higher and the RFS was markedly shorter than those in the Low-risk and even those in stage III (
p
< 0.001). In the subgroup of early stage (stage I and II), the 5-year CRR of the High-risk group was significantly higher and the RFS was significantly shorter than those in stage IIIA and IIIB (
p
< 0.001), which is similar to IIIC. In conclusion, preoperatively elevated levels of serum PT and CEA were reliable predictors of postoperative high-risk recurrence in CRC and combined with TNM stage precisely identify postoperative recurrence CRC patients in stage I–III and the benefit of adjuvant chemotherapy for patients with stage II CRC.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35322387</pmid><doi>10.1007/s13304-022-01268-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3189-8450</orcidid></addata></record> |
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| subjects | Biological markers Blood Cancer Care and treatment Chemotherapy Colorectal cancer Diseases Medical examination Medicine Medicine & Public Health Oncology, Experimental Original Article Prognosis Prothrombin Relapse Surgery Thrombin |
| title | Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I–III colorectal cancer: a retrospective cohort study |
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