Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial
Experimental and some clinical studies have shown beneficial effects of rosemary leaf on liver function and biochemical parameters. The present study aimed to examine the impact of rosemary leaf powder with a weight loss diet in patients with nonalcoholic fatty liver disease. In a randomized double‐...
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| Veröffentlicht in: | Phytotherapy research 2022-05, Vol.36 (5), p.2186-2196 |
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| creator | Akbari, Shayan Sohouli, Mohammad Hassan Ebrahimzadeh, Saeedeh Ghanaei, Fariborz Mansour Hosseini, Agha Fatemeh Aryaeian, Naheed |
| description | Experimental and some clinical studies have shown beneficial effects of rosemary leaf on liver function and biochemical parameters. The present study aimed to examine the impact of rosemary leaf powder with a weight loss diet in patients with nonalcoholic fatty liver disease. In a randomized double‐blinded clinical trial, 110 patients were randomly assigned to receive either 4 g rosemary leaf or placebo (starch) powders for 8 weeks. In addition, all participants in the study were given weight loss diet and physical activity recommendations. Compared with baseline, alanine aminotransferase (p |
| doi_str_mv | 10.1002/ptr.7446 |
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The present study aimed to examine the impact of rosemary leaf powder with a weight loss diet in patients with nonalcoholic fatty liver disease. In a randomized double‐blinded clinical trial, 110 patients were randomly assigned to receive either 4 g rosemary leaf or placebo (starch) powders for 8 weeks. In addition, all participants in the study were given weight loss diet and physical activity recommendations. Compared with baseline, alanine aminotransferase (p < .001), aspartate aminotransferase (p < .001), alkaline phosphatase (p < .001), gamma glutamyltransferase (p < .001), fasting blood glucose (p < .001), fasting insulin (p < .001), insulin resistance (p < .001), total cholesterol (p = .003), triglyceride (p < .001), low‐density lipoprotein cholesterol (p < .001), and anthropometric indices (weight, body mass index, and waist circumferences) decreased significantly in the rosemary and placebo group with weight loss. However, after 8 weeks, no significant difference between the rosemary and placebo groups was detected in the variables as mentioned above except homeostasis model assessment of β‐cell dysfunction (p = .014). The findings of the current clinical trial study revealed that rosemary group did produce changes, but they were not statistically different from those produced by the diet/activity intervention alone.]]></description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.7446</identifier><identifier>PMID: 35318738</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Alanine ; Alanine transaminase ; Alkaline phosphatase ; Aspartate aminotransferase ; Beta cells ; biochemical parameters ; Blood glucose ; Body mass ; Body mass index ; Body size ; Body weight loss ; Cholesterol ; Cholesterol, LDL ; Clinical trials ; Diet ; Diet, Reducing ; Double-Blind Method ; Double-blind studies ; Fasting ; Fatty liver ; Homeostasis ; Humans ; Insulin ; Insulin Resistance ; Leaves ; Lipids ; Liver ; Liver diseases ; liver function ; Non-alcoholic Fatty Liver Disease - drug therapy ; nonalcoholic fatty liver disease ; Patients ; Physical activity ; Placebos ; Plant Extracts ; Powders - pharmacology ; Rosemary ; Rosmarinus ; Transaminases ; Triglycerides ; Weight loss</subject><ispartof>Phytotherapy research, 2022-05, Vol.36 (5), p.2186-2196</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3496-55e2950b36a154e4f33acaf86d0ed3c49febb0ea1558e54de16c03d758a0bfb03</citedby><cites>FETCH-LOGICAL-c3496-55e2950b36a154e4f33acaf86d0ed3c49febb0ea1558e54de16c03d758a0bfb03</cites><orcidid>0000-0002-6723-7112</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.7446$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.7446$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35318738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akbari, Shayan</creatorcontrib><creatorcontrib>Sohouli, Mohammad Hassan</creatorcontrib><creatorcontrib>Ebrahimzadeh, Saeedeh</creatorcontrib><creatorcontrib>Ghanaei, Fariborz Mansour</creatorcontrib><creatorcontrib>Hosseini, Agha Fatemeh</creatorcontrib><creatorcontrib>Aryaeian, Naheed</creatorcontrib><title>Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description><![CDATA[Experimental and some clinical studies have shown beneficial effects of rosemary leaf on liver function and biochemical parameters. The present study aimed to examine the impact of rosemary leaf powder with a weight loss diet in patients with nonalcoholic fatty liver disease. In a randomized double‐blinded clinical trial, 110 patients were randomly assigned to receive either 4 g rosemary leaf or placebo (starch) powders for 8 weeks. In addition, all participants in the study were given weight loss diet and physical activity recommendations. Compared with baseline, alanine aminotransferase (p < .001), aspartate aminotransferase (p < .001), alkaline phosphatase (p < .001), gamma glutamyltransferase (p < .001), fasting blood glucose (p < .001), fasting insulin (p < .001), insulin resistance (p < .001), total cholesterol (p = .003), triglyceride (p < .001), low‐density lipoprotein cholesterol (p < .001), and anthropometric indices (weight, body mass index, and waist circumferences) decreased significantly in the rosemary and placebo group with weight loss. However, after 8 weeks, no significant difference between the rosemary and placebo groups was detected in the variables as mentioned above except homeostasis model assessment of β‐cell dysfunction (p = .014). The findings of the current clinical trial study revealed that rosemary group did produce changes, but they were not statistically different from those produced by the diet/activity intervention alone.]]></description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Aspartate aminotransferase</subject><subject>Beta cells</subject><subject>biochemical parameters</subject><subject>Blood glucose</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight loss</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL</subject><subject>Clinical trials</subject><subject>Diet</subject><subject>Diet, Reducing</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Fasting</subject><subject>Fatty liver</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Leaves</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>liver function</subject><subject>Non-alcoholic Fatty Liver Disease - drug therapy</subject><subject>nonalcoholic fatty liver disease</subject><subject>Patients</subject><subject>Physical activity</subject><subject>Placebos</subject><subject>Plant Extracts</subject><subject>Powders - pharmacology</subject><subject>Rosemary</subject><subject>Rosmarinus</subject><subject>Transaminases</subject><subject>Triglycerides</subject><subject>Weight loss</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1qFTEUgIMo9loFn0ACblzcqcnk5864K6X-QEGRCu6GTHLSm5KZjJNML9OVj9DH6nP4JGa8VwXBTc4i3_ng8CH0nJITSkj5ekjjyYZz-QCtKKnrgooNe4hWpBa04LT6eoSexHhNCKlLwh-jIyYYrTasWqH7c2tBJxwsHkOETo0z9qAsHsLOwIh3Lm3xDtzVNmEfYsTGQaZ77N3gDB7GYJ2HNb7ys4bOaRyTSlNcY9WbzNxkBfS3cwcRux4PKjnoU9xr-9Arr8M2-LxnVUrzYcO4CCrCG3yKx-wJnbsFs8YmTK2HH9_vWu-yXefXaeVxGp3yT9Ejq3yEZ4d5jL68Pb88e19cfHz34ez0otCM17IQAspakJZJRQUHbhlTWtlKGgKGaV5baFsC-VNUILgBKjVhZiMqRVrbEnaMXu29-fRvE8TUdC5q8F71EKbYlJKXrOSyXNCX_6DXYRrzzQslN1JKxuVfoc4B4gi2GUa3dGgoaZa6Ta7bLHUz-uIgnNoOzB_wd84MFHtgl6PM_xU1ny4__xL-BIkms7o</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Akbari, Shayan</creator><creator>Sohouli, Mohammad Hassan</creator><creator>Ebrahimzadeh, Saeedeh</creator><creator>Ghanaei, Fariborz Mansour</creator><creator>Hosseini, Agha Fatemeh</creator><creator>Aryaeian, Naheed</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6723-7112</orcidid></search><sort><creationdate>202205</creationdate><title>Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial</title><author>Akbari, Shayan ; Sohouli, Mohammad Hassan ; Ebrahimzadeh, Saeedeh ; Ghanaei, Fariborz Mansour ; Hosseini, Agha Fatemeh ; Aryaeian, Naheed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3496-55e2950b36a154e4f33acaf86d0ed3c49febb0ea1558e54de16c03d758a0bfb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alkaline phosphatase</topic><topic>Aspartate aminotransferase</topic><topic>Beta cells</topic><topic>biochemical parameters</topic><topic>Blood glucose</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight loss</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL</topic><topic>Clinical trials</topic><topic>Diet</topic><topic>Diet, Reducing</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Fasting</topic><topic>Fatty liver</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Leaves</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>liver function</topic><topic>Non-alcoholic Fatty Liver Disease - drug therapy</topic><topic>nonalcoholic fatty liver disease</topic><topic>Patients</topic><topic>Physical activity</topic><topic>Placebos</topic><topic>Plant Extracts</topic><topic>Powders - pharmacology</topic><topic>Rosemary</topic><topic>Rosmarinus</topic><topic>Transaminases</topic><topic>Triglycerides</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akbari, Shayan</creatorcontrib><creatorcontrib>Sohouli, Mohammad Hassan</creatorcontrib><creatorcontrib>Ebrahimzadeh, Saeedeh</creatorcontrib><creatorcontrib>Ghanaei, Fariborz Mansour</creatorcontrib><creatorcontrib>Hosseini, Agha Fatemeh</creatorcontrib><creatorcontrib>Aryaeian, Naheed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akbari, Shayan</au><au>Sohouli, Mohammad Hassan</au><au>Ebrahimzadeh, Saeedeh</au><au>Ghanaei, Fariborz Mansour</au><au>Hosseini, Agha Fatemeh</au><au>Aryaeian, Naheed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2022-05</date><risdate>2022</risdate><volume>36</volume><issue>5</issue><spage>2186</spage><epage>2196</epage><pages>2186-2196</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract><![CDATA[Experimental and some clinical studies have shown beneficial effects of rosemary leaf on liver function and biochemical parameters. The present study aimed to examine the impact of rosemary leaf powder with a weight loss diet in patients with nonalcoholic fatty liver disease. In a randomized double‐blinded clinical trial, 110 patients were randomly assigned to receive either 4 g rosemary leaf or placebo (starch) powders for 8 weeks. In addition, all participants in the study were given weight loss diet and physical activity recommendations. Compared with baseline, alanine aminotransferase (p < .001), aspartate aminotransferase (p < .001), alkaline phosphatase (p < .001), gamma glutamyltransferase (p < .001), fasting blood glucose (p < .001), fasting insulin (p < .001), insulin resistance (p < .001), total cholesterol (p = .003), triglyceride (p < .001), low‐density lipoprotein cholesterol (p < .001), and anthropometric indices (weight, body mass index, and waist circumferences) decreased significantly in the rosemary and placebo group with weight loss. However, after 8 weeks, no significant difference between the rosemary and placebo groups was detected in the variables as mentioned above except homeostasis model assessment of β‐cell dysfunction (p = .014). The findings of the current clinical trial study revealed that rosemary group did produce changes, but they were not statistically different from those produced by the diet/activity intervention alone.]]></abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>35318738</pmid><doi>10.1002/ptr.7446</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6723-7112</orcidid></addata></record> |
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| subjects | Alanine Alanine transaminase Alkaline phosphatase Aspartate aminotransferase Beta cells biochemical parameters Blood glucose Body mass Body mass index Body size Body weight loss Cholesterol Cholesterol, LDL Clinical trials Diet Diet, Reducing Double-Blind Method Double-blind studies Fasting Fatty liver Homeostasis Humans Insulin Insulin Resistance Leaves Lipids Liver Liver diseases liver function Non-alcoholic Fatty Liver Disease - drug therapy nonalcoholic fatty liver disease Patients Physical activity Placebos Plant Extracts Powders - pharmacology Rosemary Rosmarinus Transaminases Triglycerides Weight loss |
| title | Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double‐blind clinical trial |
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