Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury
Heterogeneity is recognized as a major barrier in efforts to improve the care and outcomes of patients with traumatic brain injury (TBI). Even within the narrower stratum of moderate and severe TBI, current management approaches do not capture the complexity of this condition characterized by manifo...
Gespeichert in:
| Veröffentlicht in: | Neurocritical care 2022-08, Vol.37 (Suppl 2), p.259-266 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 266 |
|---|---|
| container_issue | Suppl 2 |
| container_start_page | 259 |
| container_title | Neurocritical care |
| container_volume | 37 |
| creator | Azad, Tej D. Shah, Pavan P. Kim, Han B. Stevens, Robert D. |
| description | Heterogeneity is recognized as a major barrier in efforts to improve the care and outcomes of patients with traumatic brain injury (TBI). Even within the narrower stratum of moderate and severe TBI, current management approaches do not capture the complexity of this condition characterized by manifold clinical, anatomical, and pathophysiologic features. One approach to heterogeneity may be to resolve undifferentiated TBI populations into endotypes, subclasses that are distinguished by shared biological characteristics. The endotype paradigm has been explored in a range of medical domains, including psychiatry, oncology, immunology, and pulmonology. In intensive care, endotypes are being investigated for syndromes such as sepsis and acute respiratory distress syndrome. This review provides an overview of the endotype paradigm as well as some of its methods and use cases. A conceptual framework is proposed for endotype research in moderate and severe TBI, together with a scientific road map for endotype discovery and validation in this population. |
| doi_str_mv | 10.1007/s12028-022-01475-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2641865317</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2641865317</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-f7730c7bf4ac41a15c08b6681fb070c4863ee4eca7061e86299cb91668fdf3b63</originalsourceid><addsrcrecordid>eNp9kMlOwzAURS0Eokw_wAJZYsMm4Cl2vISqDBKIIsracpwXmqpNip0g9e9xmwISC1bP0ju-vj4InVJySQlRV4EywrKEMJYQKlSayB10QNNUJkRLurs-C5pIzfkAHYYwI4QprdJ9NOApp0JLfYBeRnXRtKslBGzrArdTwGPbTnHb4LEHV4WqqXFV46emAG9b2FCv8Ake8MTbbmHbyuEbbyPzUM86vzpGe6WdBzjZziP0djuaDO-Tx-e7h-H1Y-K4StukVIoTp_JSWCeopakjWS5lRsucKOJEJjmAAGcVkRQyybR2uaaRKIuS55IfoYs-d-mbjw5CaxZVcDCf2xqaLhgmBc1k_KiK6PkfdNZ0vo7tDNM0ehCM8UixnnK-CcFDaZa-Wli_MpSYtXDTCzdRuNkIN-sWZ9voLl9A8XPl23AEeA-EuKrfwf--_U_sF5wcidU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2919694223</pqid></control><display><type>article</type><title>Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury</title><source>ProQuest Central (Alumni Edition)</source><source>SpringerNature Journals</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Azad, Tej D. ; Shah, Pavan P. ; Kim, Han B. ; Stevens, Robert D.</creator><creatorcontrib>Azad, Tej D. ; Shah, Pavan P. ; Kim, Han B. ; Stevens, Robert D.</creatorcontrib><description>Heterogeneity is recognized as a major barrier in efforts to improve the care and outcomes of patients with traumatic brain injury (TBI). Even within the narrower stratum of moderate and severe TBI, current management approaches do not capture the complexity of this condition characterized by manifold clinical, anatomical, and pathophysiologic features. One approach to heterogeneity may be to resolve undifferentiated TBI populations into endotypes, subclasses that are distinguished by shared biological characteristics. The endotype paradigm has been explored in a range of medical domains, including psychiatry, oncology, immunology, and pulmonology. In intensive care, endotypes are being investigated for syndromes such as sepsis and acute respiratory distress syndrome. This review provides an overview of the endotype paradigm as well as some of its methods and use cases. A conceptual framework is proposed for endotype research in moderate and severe TBI, together with a scientific road map for endotype discovery and validation in this population.</description><identifier>ISSN: 1541-6933</identifier><identifier>EISSN: 1556-0961</identifier><identifier>DOI: 10.1007/s12028-022-01475-6</identifier><identifier>PMID: 35314969</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Asthma ; Big Data in Neurocritical Care ; Biomarkers ; Brain research ; Clinical trials ; Critical Care Medicine ; Cytokines ; Disease ; Gene expression ; Genotype & phenotype ; Hypothermia ; Inflammation ; Intensive ; Intensive care ; Internal Medicine ; Intracranial pressure ; Medical prognosis ; Medical research ; Medicine ; Medicine & Public Health ; Neurology ; Neurosurgery ; Pathophysiology ; Patients ; Precision medicine ; Recovery (Medical) ; Sepsis ; Traumatic brain injury</subject><ispartof>Neurocritical care, 2022-08, Vol.37 (Suppl 2), p.259-266</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-f7730c7bf4ac41a15c08b6681fb070c4863ee4eca7061e86299cb91668fdf3b63</citedby><cites>FETCH-LOGICAL-c375t-f7730c7bf4ac41a15c08b6681fb070c4863ee4eca7061e86299cb91668fdf3b63</cites><orcidid>0000-0001-5984-7837</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12028-022-01475-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919694223?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,21392,21393,27928,27929,33534,33535,33748,33749,41492,42561,43663,43809,51323,64389,64391,64393,72473</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35314969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azad, Tej D.</creatorcontrib><creatorcontrib>Shah, Pavan P.</creatorcontrib><creatorcontrib>Kim, Han B.</creatorcontrib><creatorcontrib>Stevens, Robert D.</creatorcontrib><title>Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury</title><title>Neurocritical care</title><addtitle>Neurocrit Care</addtitle><addtitle>Neurocrit Care</addtitle><description>Heterogeneity is recognized as a major barrier in efforts to improve the care and outcomes of patients with traumatic brain injury (TBI). Even within the narrower stratum of moderate and severe TBI, current management approaches do not capture the complexity of this condition characterized by manifold clinical, anatomical, and pathophysiologic features. One approach to heterogeneity may be to resolve undifferentiated TBI populations into endotypes, subclasses that are distinguished by shared biological characteristics. The endotype paradigm has been explored in a range of medical domains, including psychiatry, oncology, immunology, and pulmonology. In intensive care, endotypes are being investigated for syndromes such as sepsis and acute respiratory distress syndrome. This review provides an overview of the endotype paradigm as well as some of its methods and use cases. A conceptual framework is proposed for endotype research in moderate and severe TBI, together with a scientific road map for endotype discovery and validation in this population.</description><subject>Asthma</subject><subject>Big Data in Neurocritical Care</subject><subject>Biomarkers</subject><subject>Brain research</subject><subject>Clinical trials</subject><subject>Critical Care Medicine</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Gene expression</subject><subject>Genotype & phenotype</subject><subject>Hypothermia</subject><subject>Inflammation</subject><subject>Intensive</subject><subject>Intensive care</subject><subject>Internal Medicine</subject><subject>Intracranial pressure</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Pathophysiology</subject><subject>Patients</subject><subject>Precision medicine</subject><subject>Recovery (Medical)</subject><subject>Sepsis</subject><subject>Traumatic brain injury</subject><issn>1541-6933</issn><issn>1556-0961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMlOwzAURS0Eokw_wAJZYsMm4Cl2vISqDBKIIsracpwXmqpNip0g9e9xmwISC1bP0ju-vj4InVJySQlRV4EywrKEMJYQKlSayB10QNNUJkRLurs-C5pIzfkAHYYwI4QprdJ9NOApp0JLfYBeRnXRtKslBGzrArdTwGPbTnHb4LEHV4WqqXFV46emAG9b2FCv8Ake8MTbbmHbyuEbbyPzUM86vzpGe6WdBzjZziP0djuaDO-Tx-e7h-H1Y-K4StukVIoTp_JSWCeopakjWS5lRsucKOJEJjmAAGcVkRQyybR2uaaRKIuS55IfoYs-d-mbjw5CaxZVcDCf2xqaLhgmBc1k_KiK6PkfdNZ0vo7tDNM0ehCM8UixnnK-CcFDaZa-Wli_MpSYtXDTCzdRuNkIN-sWZ9voLl9A8XPl23AEeA-EuKrfwf--_U_sF5wcidU</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Azad, Tej D.</creator><creator>Shah, Pavan P.</creator><creator>Kim, Han B.</creator><creator>Stevens, Robert D.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5984-7837</orcidid></search><sort><creationdate>20220801</creationdate><title>Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury</title><author>Azad, Tej D. ; Shah, Pavan P. ; Kim, Han B. ; Stevens, Robert D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-f7730c7bf4ac41a15c08b6681fb070c4863ee4eca7061e86299cb91668fdf3b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Asthma</topic><topic>Big Data in Neurocritical Care</topic><topic>Biomarkers</topic><topic>Brain research</topic><topic>Clinical trials</topic><topic>Critical Care Medicine</topic><topic>Cytokines</topic><topic>Disease</topic><topic>Gene expression</topic><topic>Genotype & phenotype</topic><topic>Hypothermia</topic><topic>Inflammation</topic><topic>Intensive</topic><topic>Intensive care</topic><topic>Internal Medicine</topic><topic>Intracranial pressure</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Pathophysiology</topic><topic>Patients</topic><topic>Precision medicine</topic><topic>Recovery (Medical)</topic><topic>Sepsis</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azad, Tej D.</creatorcontrib><creatorcontrib>Shah, Pavan P.</creatorcontrib><creatorcontrib>Kim, Han B.</creatorcontrib><creatorcontrib>Stevens, Robert D.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Neurocritical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azad, Tej D.</au><au>Shah, Pavan P.</au><au>Kim, Han B.</au><au>Stevens, Robert D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury</atitle><jtitle>Neurocritical care</jtitle><stitle>Neurocrit Care</stitle><addtitle>Neurocrit Care</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>37</volume><issue>Suppl 2</issue><spage>259</spage><epage>266</epage><pages>259-266</pages><issn>1541-6933</issn><eissn>1556-0961</eissn><abstract>Heterogeneity is recognized as a major barrier in efforts to improve the care and outcomes of patients with traumatic brain injury (TBI). Even within the narrower stratum of moderate and severe TBI, current management approaches do not capture the complexity of this condition characterized by manifold clinical, anatomical, and pathophysiologic features. One approach to heterogeneity may be to resolve undifferentiated TBI populations into endotypes, subclasses that are distinguished by shared biological characteristics. The endotype paradigm has been explored in a range of medical domains, including psychiatry, oncology, immunology, and pulmonology. In intensive care, endotypes are being investigated for syndromes such as sepsis and acute respiratory distress syndrome. This review provides an overview of the endotype paradigm as well as some of its methods and use cases. A conceptual framework is proposed for endotype research in moderate and severe TBI, together with a scientific road map for endotype discovery and validation in this population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35314969</pmid><doi>10.1007/s12028-022-01475-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5984-7837</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1541-6933 |
| ispartof | Neurocritical care, 2022-08, Vol.37 (Suppl 2), p.259-266 |
| issn | 1541-6933 1556-0961 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2641865317 |
| source | ProQuest Central (Alumni Edition); SpringerNature Journals; ProQuest Central UK/Ireland; ProQuest Central |
| subjects | Asthma Big Data in Neurocritical Care Biomarkers Brain research Clinical trials Critical Care Medicine Cytokines Disease Gene expression Genotype & phenotype Hypothermia Inflammation Intensive Intensive care Internal Medicine Intracranial pressure Medical prognosis Medical research Medicine Medicine & Public Health Neurology Neurosurgery Pathophysiology Patients Precision medicine Recovery (Medical) Sepsis Traumatic brain injury |
| title | Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T02%3A32%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endotypes%20and%20the%20Path%20to%20Precision%20in%20Moderate%20and%20Severe%20Traumatic%20Brain%20Injury&rft.jtitle=Neurocritical%20care&rft.au=Azad,%20Tej%20D.&rft.date=2022-08-01&rft.volume=37&rft.issue=Suppl%202&rft.spage=259&rft.epage=266&rft.pages=259-266&rft.issn=1541-6933&rft.eissn=1556-0961&rft_id=info:doi/10.1007/s12028-022-01475-6&rft_dat=%3Cproquest_cross%3E2641865317%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2919694223&rft_id=info:pmid/35314969&rfr_iscdi=true |