Radiologic–pathologic correlation of major versus minor extranodal extension in oral cavity cancer
Background To evaluate the diagnostic performance of radiologic extranodal extension (rENE) in predicting major (>2 mm) and minor (≤2 mm) pathologic ENE (pENE). Methods All oral cavity squamous cell carcinoma patients who underwent neck dissection with pathological nodal disease (pN+) between 201...
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| Veröffentlicht in: | Head & neck 2022-06, Vol.44 (6), p.1422-1429 |
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| creator | Blasco, Michael A. Noel, Christopher W. Truong, Tra Huang, Shao Hui Goldstein, David P. Irish, Jonathan C. Gilbert, Ralph Hosni, Ali Hope, Andrew O'Sullivan, Brian Waldron, John Perez‐Ordonez, Bayardo Weinreb, Ilan Smith, Stephen M. Bartlett, Eric Yu, Eugene Almeida, John R. |
| description | Background
To evaluate the diagnostic performance of radiologic extranodal extension (rENE) in predicting major (>2 mm) and minor (≤2 mm) pathologic ENE (pENE).
Methods
All oral cavity squamous cell carcinoma patients who underwent neck dissection with pathological nodal disease (pN+) between 2010 and 2015 were reviewed. Preoperative computed tomography and/or magnetic resonance imaging were reviewed by two head and neck neuroradiologists.
Results
Three hundred and thirty‐four patients were included. The sensitivity and specificity of rENE were 37% [95% CI 29–44] and 98% [95% CI 96–100], respectively. Sensitivity for pENE improved in the subset of patients with major ENE (48% [95% CI 38–57]). The presence of rENE was associated with inferior 3‐year overall survival: 26% [95% CI 17–41] versus 60% [95% CI 54–67].
Conclusions
This large cohort study demonstrates high specificity, but low sensitivity for preoperative imaging in the detection of pENE in OCSCC. Patients with rENE demonstrated poor OS. pENE in the absence of rENE is still an adverse risk factor. |
| doi_str_mv | 10.1002/hed.27036 |
| format | Article |
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To evaluate the diagnostic performance of radiologic extranodal extension (rENE) in predicting major (>2 mm) and minor (≤2 mm) pathologic ENE (pENE).
Methods
All oral cavity squamous cell carcinoma patients who underwent neck dissection with pathological nodal disease (pN+) between 2010 and 2015 were reviewed. Preoperative computed tomography and/or magnetic resonance imaging were reviewed by two head and neck neuroradiologists.
Results
Three hundred and thirty‐four patients were included. The sensitivity and specificity of rENE were 37% [95% CI 29–44] and 98% [95% CI 96–100], respectively. Sensitivity for pENE improved in the subset of patients with major ENE (48% [95% CI 38–57]). The presence of rENE was associated with inferior 3‐year overall survival: 26% [95% CI 17–41] versus 60% [95% CI 54–67].
Conclusions
This large cohort study demonstrates high specificity, but low sensitivity for preoperative imaging in the detection of pENE in OCSCC. Patients with rENE demonstrated poor OS. pENE in the absence of rENE is still an adverse risk factor.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27036</identifier><identifier>PMID: 35315548</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cohort Studies ; Computed tomography ; diagnostic imaging ; Extranodal Extension ; Head & neck cancer ; head and neck neoplasms ; Head and Neck Neoplasms - pathology ; Humans ; Magnetic resonance imaging ; mortality ; Mouth Neoplasms - diagnostic imaging ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Neoplasm Staging ; Oral carcinoma ; Oral cavity ; oral cavity cancer ; pathology ; predictive value of tests ; Prognosis ; Retrospective Studies ; Risk factors ; Squamous cell carcinoma ; staging</subject><ispartof>Head & neck, 2022-06, Vol.44 (6), p.1422-1429</ispartof><rights>2022 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-bc8398d88e4b5a5db0c06c7824bc0db47c545f594a788531d4cd848367fed4b43</citedby><cites>FETCH-LOGICAL-c3536-bc8398d88e4b5a5db0c06c7824bc0db47c545f594a788531d4cd848367fed4b43</cites><orcidid>0000-0003-0464-5087 ; 0000-0002-6625-0809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27036$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27036$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35315548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blasco, Michael A.</creatorcontrib><creatorcontrib>Noel, Christopher W.</creatorcontrib><creatorcontrib>Truong, Tra</creatorcontrib><creatorcontrib>Huang, Shao Hui</creatorcontrib><creatorcontrib>Goldstein, David P.</creatorcontrib><creatorcontrib>Irish, Jonathan C.</creatorcontrib><creatorcontrib>Gilbert, Ralph</creatorcontrib><creatorcontrib>Hosni, Ali</creatorcontrib><creatorcontrib>Hope, Andrew</creatorcontrib><creatorcontrib>O'Sullivan, Brian</creatorcontrib><creatorcontrib>Waldron, John</creatorcontrib><creatorcontrib>Perez‐Ordonez, Bayardo</creatorcontrib><creatorcontrib>Weinreb, Ilan</creatorcontrib><creatorcontrib>Smith, Stephen M.</creatorcontrib><creatorcontrib>Bartlett, Eric</creatorcontrib><creatorcontrib>Yu, Eugene</creatorcontrib><creatorcontrib>Almeida, John R.</creatorcontrib><title>Radiologic–pathologic correlation of major versus minor extranodal extension in oral cavity cancer</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
To evaluate the diagnostic performance of radiologic extranodal extension (rENE) in predicting major (>2 mm) and minor (≤2 mm) pathologic ENE (pENE).
Methods
All oral cavity squamous cell carcinoma patients who underwent neck dissection with pathological nodal disease (pN+) between 2010 and 2015 were reviewed. Preoperative computed tomography and/or magnetic resonance imaging were reviewed by two head and neck neuroradiologists.
Results
Three hundred and thirty‐four patients were included. The sensitivity and specificity of rENE were 37% [95% CI 29–44] and 98% [95% CI 96–100], respectively. Sensitivity for pENE improved in the subset of patients with major ENE (48% [95% CI 38–57]). The presence of rENE was associated with inferior 3‐year overall survival: 26% [95% CI 17–41] versus 60% [95% CI 54–67].
Conclusions
This large cohort study demonstrates high specificity, but low sensitivity for preoperative imaging in the detection of pENE in OCSCC. Patients with rENE demonstrated poor OS. pENE in the absence of rENE is still an adverse risk factor.</description><subject>Cohort Studies</subject><subject>Computed tomography</subject><subject>diagnostic imaging</subject><subject>Extranodal Extension</subject><subject>Head & neck cancer</subject><subject>head and neck neoplasms</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>mortality</subject><subject>Mouth Neoplasms - diagnostic imaging</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neoplasm Staging</subject><subject>Oral carcinoma</subject><subject>Oral cavity</subject><subject>oral cavity cancer</subject><subject>pathology</subject><subject>predictive value of tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Squamous cell carcinoma</subject><subject>staging</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EFLwzAUB_AgipvTg19ACl700C1tkiY9ypxOGAii55Imqctom5m00938Dn5DP4mp3S6Cp_fy-PF4-QNwHsFxBGE8WSo5jilEyQEYRjClIUSYHnY9RiGCFA_AiXMrCD3B8TEYIIIiQjAbAvnEpTaledXi-_NrzZtl_wiEsVaVvNGmDkwRVHxlbLBR1rUuqHTtH-qjsbw2kpddq2rXUe219RPBN7rZ-lILZU_BUcFLp852dQRe7mbP03m4eLx_mN4sQuEPSsJcMJQyyZjCOeFE5lDARFAW41xAmWMqCCYFSTGnjPkfSCwkwwwltFAS5xiNwFW_d23NW6tck1XaCVWWvFamdVmc4IglOEUdvfxDV6a1tb_OK8LSlNAk9uq6V8Ia56wqsrXVFbfbLIJZF33mo89-o_f2YrexzSs_3ct91h5MevCuS7X9f1M2n932K38AQB2O9Q</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Blasco, Michael A.</creator><creator>Noel, Christopher W.</creator><creator>Truong, Tra</creator><creator>Huang, Shao Hui</creator><creator>Goldstein, David P.</creator><creator>Irish, Jonathan C.</creator><creator>Gilbert, Ralph</creator><creator>Hosni, Ali</creator><creator>Hope, Andrew</creator><creator>O'Sullivan, Brian</creator><creator>Waldron, John</creator><creator>Perez‐Ordonez, Bayardo</creator><creator>Weinreb, Ilan</creator><creator>Smith, Stephen M.</creator><creator>Bartlett, Eric</creator><creator>Yu, Eugene</creator><creator>Almeida, John R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0464-5087</orcidid><orcidid>https://orcid.org/0000-0002-6625-0809</orcidid></search><sort><creationdate>202206</creationdate><title>Radiologic–pathologic correlation of major versus minor extranodal extension in oral cavity cancer</title><author>Blasco, Michael A. ; Noel, Christopher W. ; Truong, Tra ; Huang, Shao Hui ; Goldstein, David P. ; Irish, Jonathan C. ; Gilbert, Ralph ; Hosni, Ali ; Hope, Andrew ; O'Sullivan, Brian ; Waldron, John ; Perez‐Ordonez, Bayardo ; Weinreb, Ilan ; Smith, Stephen M. ; Bartlett, Eric ; Yu, Eugene ; Almeida, John R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-bc8398d88e4b5a5db0c06c7824bc0db47c545f594a788531d4cd848367fed4b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cohort Studies</topic><topic>Computed tomography</topic><topic>diagnostic imaging</topic><topic>Extranodal Extension</topic><topic>Head & neck cancer</topic><topic>head and neck neoplasms</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>mortality</topic><topic>Mouth Neoplasms - diagnostic imaging</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neoplasm Staging</topic><topic>Oral carcinoma</topic><topic>Oral cavity</topic><topic>oral cavity cancer</topic><topic>pathology</topic><topic>predictive value of tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Squamous cell carcinoma</topic><topic>staging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blasco, Michael A.</creatorcontrib><creatorcontrib>Noel, Christopher W.</creatorcontrib><creatorcontrib>Truong, Tra</creatorcontrib><creatorcontrib>Huang, Shao Hui</creatorcontrib><creatorcontrib>Goldstein, David P.</creatorcontrib><creatorcontrib>Irish, Jonathan C.</creatorcontrib><creatorcontrib>Gilbert, Ralph</creatorcontrib><creatorcontrib>Hosni, Ali</creatorcontrib><creatorcontrib>Hope, Andrew</creatorcontrib><creatorcontrib>O'Sullivan, Brian</creatorcontrib><creatorcontrib>Waldron, John</creatorcontrib><creatorcontrib>Perez‐Ordonez, Bayardo</creatorcontrib><creatorcontrib>Weinreb, Ilan</creatorcontrib><creatorcontrib>Smith, Stephen M.</creatorcontrib><creatorcontrib>Bartlett, Eric</creatorcontrib><creatorcontrib>Yu, Eugene</creatorcontrib><creatorcontrib>Almeida, John R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blasco, Michael A.</au><au>Noel, Christopher W.</au><au>Truong, Tra</au><au>Huang, Shao Hui</au><au>Goldstein, David P.</au><au>Irish, Jonathan C.</au><au>Gilbert, Ralph</au><au>Hosni, Ali</au><au>Hope, Andrew</au><au>O'Sullivan, Brian</au><au>Waldron, John</au><au>Perez‐Ordonez, Bayardo</au><au>Weinreb, Ilan</au><au>Smith, Stephen M.</au><au>Bartlett, Eric</au><au>Yu, Eugene</au><au>Almeida, John R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiologic–pathologic correlation of major versus minor extranodal extension in oral cavity cancer</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2022-06</date><risdate>2022</risdate><volume>44</volume><issue>6</issue><spage>1422</spage><epage>1429</epage><pages>1422-1429</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
To evaluate the diagnostic performance of radiologic extranodal extension (rENE) in predicting major (>2 mm) and minor (≤2 mm) pathologic ENE (pENE).
Methods
All oral cavity squamous cell carcinoma patients who underwent neck dissection with pathological nodal disease (pN+) between 2010 and 2015 were reviewed. Preoperative computed tomography and/or magnetic resonance imaging were reviewed by two head and neck neuroradiologists.
Results
Three hundred and thirty‐four patients were included. The sensitivity and specificity of rENE were 37% [95% CI 29–44] and 98% [95% CI 96–100], respectively. Sensitivity for pENE improved in the subset of patients with major ENE (48% [95% CI 38–57]). The presence of rENE was associated with inferior 3‐year overall survival: 26% [95% CI 17–41] versus 60% [95% CI 54–67].
Conclusions
This large cohort study demonstrates high specificity, but low sensitivity for preoperative imaging in the detection of pENE in OCSCC. Patients with rENE demonstrated poor OS. pENE in the absence of rENE is still an adverse risk factor.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>35315548</pmid><doi>10.1002/hed.27036</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0464-5087</orcidid><orcidid>https://orcid.org/0000-0002-6625-0809</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cohort Studies Computed tomography diagnostic imaging Extranodal Extension Head & neck cancer head and neck neoplasms Head and Neck Neoplasms - pathology Humans Magnetic resonance imaging mortality Mouth Neoplasms - diagnostic imaging Mouth Neoplasms - pathology Mouth Neoplasms - surgery Neoplasm Staging Oral carcinoma Oral cavity oral cavity cancer pathology predictive value of tests Prognosis Retrospective Studies Risk factors Squamous cell carcinoma staging |
| title | Radiologic–pathologic correlation of major versus minor extranodal extension in oral cavity cancer |
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