Geospatial analysis of Helicobacter pylori infection in South Australia: Should location influence eradication therapy?
Background and Aim Rates of antimicrobial‐resistant Helicobacter pylori infection are rising globally; however, geospatial location and its interaction with risk factors for infection have not been closely examined. Methods Gastric biopsy specimens were collected to detect H. pylori infection at mul...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2022-07, Vol.37 (7), p.1263-1274 |
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| creator | Schubert, Jonathon P Woodman, Richard J Mangoni, Arduino A Rayner, Christopher K Warner, Morgyn S Roberts‐Thomson, Ian C Costello, Samuel P Bryant, Robert V |
| description | Background and Aim
Rates of antimicrobial‐resistant Helicobacter pylori infection are rising globally; however, geospatial location and its interaction with risk factors for infection have not been closely examined.
Methods
Gastric biopsy specimens were collected to detect H. pylori infection at multiple centers in Adelaide, South Australia, between 1998 and 2017. The geospatial distribution of antibiotic‐resistant H. pylori in the Greater Adelaide region was plotted using choropleth maps. Moran's I was used to assess geospatial correlation, and multivariate linear regression (MLR) was used to examine associations between migration status, socioeconomic status, age, gender, and rates of H. pylori positivity and antibiotic resistance. Geographically weighted regression (GWR) was used to determine the extent to which the associations varied according to geospatial location.
Results
Of 20 108 biopsies across 136 postcodes within the Greater Adelaide region, 1901 (9.45%) were H. pylori positive. Of these, 797 (41.9%) displayed clarithromycin, tetracycline, metronidazole, or amoxicillin resistance. In MLR, migration status was associated with the rate of H. pylori positivity (β = 3.85% per 10% increase in a postcode's migrant population; P |
| doi_str_mv | 10.1111/jgh.15832 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2641863626</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2641863626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3882-86d334422ff5ef2690fbddfd3af0df1d2b0ffcfd17ef57ce933ad44eb7b7dd0a3</originalsourceid><addsrcrecordid>eNp10ctO3DAUBmCrKirDZdEXqCx1QxcBO74k6QYhVGZASCyAdeTYxx2PPHFqJ0J5ewwz7aIS3tjH-vQvzo_QV0rOaT4Xm9_rcypqVn5CC8o5KWjF5We0IDUVRcNoc4iOUtoQQjipxBd0yASjQvBqgV6WENKgRqc8Vr3yc3IJB4tX4J0OndIjRDzMPkSHXW9Bjy70-YUfwzSu8dWUxqi8Uz_x4zpM3mAftNob6yfoNWCIyrj977jO0zBfnqADq3yC0_19jJ5vfj1dr4r7h-Xt9dV9oVldl0UtDWOcl6W1AmwpG2I7Y6xhyhJjqSk7Yq22hlZgRaWhYUwZzqGrusoYotgxOtvlDjH8mSCN7dYlDd6rHsKU2lJyWksmS5np9__oJkwx7-RN1ZIIzmWT1Y-d0jGkFMG2Q3RbFeeWkvatjTa30b63ke23feLUbcH8k3_Xn8HFDrw4D_PHSe3dcrWLfAWAppac</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2686054469</pqid></control><display><type>article</type><title>Geospatial analysis of Helicobacter pylori infection in South Australia: Should location influence eradication therapy?</title><source>Access via Wiley Online Library</source><source>MEDLINE</source><creator>Schubert, Jonathon P ; Woodman, Richard J ; Mangoni, Arduino A ; Rayner, Christopher K ; Warner, Morgyn S ; Roberts‐Thomson, Ian C ; Costello, Samuel P ; Bryant, Robert V</creator><creatorcontrib>Schubert, Jonathon P ; Woodman, Richard J ; Mangoni, Arduino A ; Rayner, Christopher K ; Warner, Morgyn S ; Roberts‐Thomson, Ian C ; Costello, Samuel P ; Bryant, Robert V</creatorcontrib><description>Background and Aim
Rates of antimicrobial‐resistant Helicobacter pylori infection are rising globally; however, geospatial location and its interaction with risk factors for infection have not been closely examined.
Methods
Gastric biopsy specimens were collected to detect H. pylori infection at multiple centers in Adelaide, South Australia, between 1998 and 2017. The geospatial distribution of antibiotic‐resistant H. pylori in the Greater Adelaide region was plotted using choropleth maps. Moran's I was used to assess geospatial correlation, and multivariate linear regression (MLR) was used to examine associations between migration status, socioeconomic status, age, gender, and rates of H. pylori positivity and antibiotic resistance. Geographically weighted regression (GWR) was used to determine the extent to which the associations varied according to geospatial location.
Results
Of 20 108 biopsies across 136 postcodes within the Greater Adelaide region, 1901 (9.45%) were H. pylori positive. Of these, 797 (41.9%) displayed clarithromycin, tetracycline, metronidazole, or amoxicillin resistance. In MLR, migration status was associated with the rate of H. pylori positivity (β = 3.85% per 10% increase in a postcode's migrant population; P < 0.001). H. pylori positivity and resistance to any antibiotic were geospatially clustered (Moran's I = 0.571 and 0.280, respectively; P < 0.001 for both). In GWR, there was significant geospatial variation in the strength of the migrant association for both H. pylori positivity and antibiotic resistance.
Conclusion
Our study demonstrates the heterogeneous geospatial distribution of H. pylori positivity and antibiotic resistance, as well as its interaction with migrant status. Geographic location and migrant status are important factors to consider for H. pylori eradication therapy.</description><identifier>ISSN: 0815-9319</identifier><identifier>ISSN: 1440-1746</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.15832</identifier><identifier>PMID: 35315547</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Amoxicillin ; Amoxicillin - therapeutic use ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotic resistance ; Antibiotics ; antimicrobial ; antimicrobial resistance ; Biopsy ; Clarithromycin ; Drug resistance ; Drug Resistance, Bacterial ; Eradication ; geospatial ; Helicobacter Infections - drug therapy ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Humans ; Infections ; Metronidazole ; Microbial Sensitivity Tests ; resistance ; Risk factors ; South Australia - epidemiology</subject><ispartof>Journal of gastroenterology and hepatology, 2022-07, Vol.37 (7), p.1263-1274</ispartof><rights>2022 The Authors. published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2022 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-86d334422ff5ef2690fbddfd3af0df1d2b0ffcfd17ef57ce933ad44eb7b7dd0a3</citedby><cites>FETCH-LOGICAL-c3882-86d334422ff5ef2690fbddfd3af0df1d2b0ffcfd17ef57ce933ad44eb7b7dd0a3</cites><orcidid>0000-0001-7201-1188</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.15832$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.15832$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35315547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schubert, Jonathon P</creatorcontrib><creatorcontrib>Woodman, Richard J</creatorcontrib><creatorcontrib>Mangoni, Arduino A</creatorcontrib><creatorcontrib>Rayner, Christopher K</creatorcontrib><creatorcontrib>Warner, Morgyn S</creatorcontrib><creatorcontrib>Roberts‐Thomson, Ian C</creatorcontrib><creatorcontrib>Costello, Samuel P</creatorcontrib><creatorcontrib>Bryant, Robert V</creatorcontrib><title>Geospatial analysis of Helicobacter pylori infection in South Australia: Should location influence eradication therapy?</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Rates of antimicrobial‐resistant Helicobacter pylori infection are rising globally; however, geospatial location and its interaction with risk factors for infection have not been closely examined.
Methods
Gastric biopsy specimens were collected to detect H. pylori infection at multiple centers in Adelaide, South Australia, between 1998 and 2017. The geospatial distribution of antibiotic‐resistant H. pylori in the Greater Adelaide region was plotted using choropleth maps. Moran's I was used to assess geospatial correlation, and multivariate linear regression (MLR) was used to examine associations between migration status, socioeconomic status, age, gender, and rates of H. pylori positivity and antibiotic resistance. Geographically weighted regression (GWR) was used to determine the extent to which the associations varied according to geospatial location.
Results
Of 20 108 biopsies across 136 postcodes within the Greater Adelaide region, 1901 (9.45%) were H. pylori positive. Of these, 797 (41.9%) displayed clarithromycin, tetracycline, metronidazole, or amoxicillin resistance. In MLR, migration status was associated with the rate of H. pylori positivity (β = 3.85% per 10% increase in a postcode's migrant population; P < 0.001). H. pylori positivity and resistance to any antibiotic were geospatially clustered (Moran's I = 0.571 and 0.280, respectively; P < 0.001 for both). In GWR, there was significant geospatial variation in the strength of the migrant association for both H. pylori positivity and antibiotic resistance.
Conclusion
Our study demonstrates the heterogeneous geospatial distribution of H. pylori positivity and antibiotic resistance, as well as its interaction with migrant status. Geographic location and migrant status are important factors to consider for H. pylori eradication therapy.</description><subject>Amoxicillin</subject><subject>Amoxicillin - therapeutic use</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>antimicrobial</subject><subject>antimicrobial resistance</subject><subject>Biopsy</subject><subject>Clarithromycin</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>Eradication</subject><subject>geospatial</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Infections</subject><subject>Metronidazole</subject><subject>Microbial Sensitivity Tests</subject><subject>resistance</subject><subject>Risk factors</subject><subject>South Australia - epidemiology</subject><issn>0815-9319</issn><issn>1440-1746</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp10ctO3DAUBmCrKirDZdEXqCx1QxcBO74k6QYhVGZASCyAdeTYxx2PPHFqJ0J5ewwz7aIS3tjH-vQvzo_QV0rOaT4Xm9_rcypqVn5CC8o5KWjF5We0IDUVRcNoc4iOUtoQQjipxBd0yASjQvBqgV6WENKgRqc8Vr3yc3IJB4tX4J0OndIjRDzMPkSHXW9Bjy70-YUfwzSu8dWUxqi8Uz_x4zpM3mAftNob6yfoNWCIyrj977jO0zBfnqADq3yC0_19jJ5vfj1dr4r7h-Xt9dV9oVldl0UtDWOcl6W1AmwpG2I7Y6xhyhJjqSk7Yq22hlZgRaWhYUwZzqGrusoYotgxOtvlDjH8mSCN7dYlDd6rHsKU2lJyWksmS5np9__oJkwx7-RN1ZIIzmWT1Y-d0jGkFMG2Q3RbFeeWkvatjTa30b63ke23feLUbcH8k3_Xn8HFDrw4D_PHSe3dcrWLfAWAppac</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Schubert, Jonathon P</creator><creator>Woodman, Richard J</creator><creator>Mangoni, Arduino A</creator><creator>Rayner, Christopher K</creator><creator>Warner, Morgyn S</creator><creator>Roberts‐Thomson, Ian C</creator><creator>Costello, Samuel P</creator><creator>Bryant, Robert V</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7201-1188</orcidid></search><sort><creationdate>202207</creationdate><title>Geospatial analysis of Helicobacter pylori infection in South Australia: Should location influence eradication therapy?</title><author>Schubert, Jonathon P ; Woodman, Richard J ; Mangoni, Arduino A ; Rayner, Christopher K ; Warner, Morgyn S ; Roberts‐Thomson, Ian C ; Costello, Samuel P ; Bryant, Robert V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-86d334422ff5ef2690fbddfd3af0df1d2b0ffcfd17ef57ce933ad44eb7b7dd0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amoxicillin</topic><topic>Amoxicillin - therapeutic use</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>antimicrobial</topic><topic>antimicrobial resistance</topic><topic>Biopsy</topic><topic>Clarithromycin</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial</topic><topic>Eradication</topic><topic>geospatial</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Infections</topic><topic>Metronidazole</topic><topic>Microbial Sensitivity Tests</topic><topic>resistance</topic><topic>Risk factors</topic><topic>South Australia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schubert, Jonathon P</creatorcontrib><creatorcontrib>Woodman, Richard J</creatorcontrib><creatorcontrib>Mangoni, Arduino A</creatorcontrib><creatorcontrib>Rayner, Christopher K</creatorcontrib><creatorcontrib>Warner, Morgyn S</creatorcontrib><creatorcontrib>Roberts‐Thomson, Ian C</creatorcontrib><creatorcontrib>Costello, Samuel P</creatorcontrib><creatorcontrib>Bryant, Robert V</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schubert, Jonathon P</au><au>Woodman, Richard J</au><au>Mangoni, Arduino A</au><au>Rayner, Christopher K</au><au>Warner, Morgyn S</au><au>Roberts‐Thomson, Ian C</au><au>Costello, Samuel P</au><au>Bryant, Robert V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Geospatial analysis of Helicobacter pylori infection in South Australia: Should location influence eradication therapy?</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2022-07</date><risdate>2022</risdate><volume>37</volume><issue>7</issue><spage>1263</spage><epage>1274</epage><pages>1263-1274</pages><issn>0815-9319</issn><issn>1440-1746</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Rates of antimicrobial‐resistant Helicobacter pylori infection are rising globally; however, geospatial location and its interaction with risk factors for infection have not been closely examined.
Methods
Gastric biopsy specimens were collected to detect H. pylori infection at multiple centers in Adelaide, South Australia, between 1998 and 2017. The geospatial distribution of antibiotic‐resistant H. pylori in the Greater Adelaide region was plotted using choropleth maps. Moran's I was used to assess geospatial correlation, and multivariate linear regression (MLR) was used to examine associations between migration status, socioeconomic status, age, gender, and rates of H. pylori positivity and antibiotic resistance. Geographically weighted regression (GWR) was used to determine the extent to which the associations varied according to geospatial location.
Results
Of 20 108 biopsies across 136 postcodes within the Greater Adelaide region, 1901 (9.45%) were H. pylori positive. Of these, 797 (41.9%) displayed clarithromycin, tetracycline, metronidazole, or amoxicillin resistance. In MLR, migration status was associated with the rate of H. pylori positivity (β = 3.85% per 10% increase in a postcode's migrant population; P < 0.001). H. pylori positivity and resistance to any antibiotic were geospatially clustered (Moran's I = 0.571 and 0.280, respectively; P < 0.001 for both). In GWR, there was significant geospatial variation in the strength of the migrant association for both H. pylori positivity and antibiotic resistance.
Conclusion
Our study demonstrates the heterogeneous geospatial distribution of H. pylori positivity and antibiotic resistance, as well as its interaction with migrant status. Geographic location and migrant status are important factors to consider for H. pylori eradication therapy.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35315547</pmid><doi>10.1111/jgh.15832</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7201-1188</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amoxicillin Amoxicillin - therapeutic use Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics antimicrobial antimicrobial resistance Biopsy Clarithromycin Drug resistance Drug Resistance, Bacterial Eradication geospatial Helicobacter Infections - drug therapy Helicobacter Infections - epidemiology Helicobacter pylori Humans Infections Metronidazole Microbial Sensitivity Tests resistance Risk factors South Australia - epidemiology |
| title | Geospatial analysis of Helicobacter pylori infection in South Australia: Should location influence eradication therapy? |
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