Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis
Objective Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases. Th...
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| Veröffentlicht in: | Neurological sciences 2022-07, Vol.43 (7), p.4125-4132 |
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| creator | Wang, Yashan Hu, Jiayi Chen, Xiaofei Wang, Song Zhang, Chenyang Hu, Junjun Guo, Dingjie Liu, Xin |
| description | Objective
Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases. This meta-analysis was performed to evaluate the diagnostic accuracy of RT-QuIC for Lewy body diseases.
Methods
This study followed the PRISMA statement. We searched six databases for relevant studies published until February 20, 2022. Meta-analysis was conducted using RevMan 5.3, Stata 17.0, and Meta-Disc 1.4. Subgroup analyses were performed to explore sources of heterogeneity.
Results
A total of 16 studies were included in this study. The pooled sensitivity and specificity were 0.91 (95%CI: 0.85–0.94) and 0.95 (95%CI: 0.90–0.97), respectively. The pooled positive and negative likelihood ratios were 17.16 (95% CI: 9.16–32.14) and 0.10 (95% CI: 0.06–0.17), respectively. The pooled diagnostic odds rate and area under the summary receiver operating characteristic curve were 171.16 (95% CI: 66.64–439.62) and 0.97 (95% CI: 0.96–0.99), respectively.
Conclusions
This study was the first meta-analysis on RT-QuIC for Lewy body diseases. RT-QuIC is a reliable and accurate method to diagnose Lewy body diseases. |
| doi_str_mv | 10.1007/s10072-022-06014-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2641857708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2678988339</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e759c9f9fd2cdf45f588bb04693f70f9727a6162885c6515fc87c25cea61cd653</originalsourceid><addsrcrecordid>eNp9kE1vFSEUhonR2A_9Ay4MiRs3WD6GAdyZRq3JTZoY3Uq4zKGhzkfLmamdf1-u96qJiy44kMNzXshDyCvB3wnOzRnuqmRc1tVy0bD7J-RYaMeZaox9ejgLa5ojcoJ4zXmFhHpOjpRWQlrjjsmPrxB6NucB6O0SfubxiuWxWyJ0NE7jHRTM00gDYlhpRhpiXEqYgaap0A38Wul26lbaZYSAgO9poAPMgYUx9CtmfEGepdAjvDzsp-T7p4_fzi_Y5vLzl_MPGxaV0TMDo110yaVOxi41Omlrt1vetE4lw5Mz0oRWtNJaHVstdIrWRKkj1G7sWq1Oydt97k2ZbhfA2Q8ZI_R9GGFa0Mu2EVYbw21F3_yHXk9Lqf_dUcY6a5VylZJ7KpYJsUDyNyUPoaxecL_z7vf2fbXvf9v393Xo9SF62Q7Q_R35o7sCag9gvRqvoPx7-5HYB5GOj_w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2678988339</pqid></control><display><type>article</type><title>Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis</title><source>Springer Nature - Complete Springer Journals</source><creator>Wang, Yashan ; Hu, Jiayi ; Chen, Xiaofei ; Wang, Song ; Zhang, Chenyang ; Hu, Junjun ; Guo, Dingjie ; Liu, Xin</creator><creatorcontrib>Wang, Yashan ; Hu, Jiayi ; Chen, Xiaofei ; Wang, Song ; Zhang, Chenyang ; Hu, Junjun ; Guo, Dingjie ; Liu, Xin</creatorcontrib><description>Objective
Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases. This meta-analysis was performed to evaluate the diagnostic accuracy of RT-QuIC for Lewy body diseases.
Methods
This study followed the PRISMA statement. We searched six databases for relevant studies published until February 20, 2022. Meta-analysis was conducted using RevMan 5.3, Stata 17.0, and Meta-Disc 1.4. Subgroup analyses were performed to explore sources of heterogeneity.
Results
A total of 16 studies were included in this study. The pooled sensitivity and specificity were 0.91 (95%CI: 0.85–0.94) and 0.95 (95%CI: 0.90–0.97), respectively. The pooled positive and negative likelihood ratios were 17.16 (95% CI: 9.16–32.14) and 0.10 (95% CI: 0.06–0.17), respectively. The pooled diagnostic odds rate and area under the summary receiver operating characteristic curve were 171.16 (95% CI: 66.64–439.62) and 0.97 (95% CI: 0.96–0.99), respectively.
Conclusions
This study was the first meta-analysis on RT-QuIC for Lewy body diseases. RT-QuIC is a reliable and accurate method to diagnose Lewy body diseases.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-022-06014-x</identifier><identifier>PMID: 35312879</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Lewy bodies ; Medicine ; Medicine & Public Health ; Meta-analysis ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Psychiatry ; Review Article ; Synuclein</subject><ispartof>Neurological sciences, 2022-07, Vol.43 (7), p.4125-4132</ispartof><rights>Fondazione Società Italiana di Neurologia 2022</rights><rights>2022. Fondazione Società Italiana di Neurologia.</rights><rights>Fondazione Società Italiana di Neurologia 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e759c9f9fd2cdf45f588bb04693f70f9727a6162885c6515fc87c25cea61cd653</citedby><cites>FETCH-LOGICAL-c375t-e759c9f9fd2cdf45f588bb04693f70f9727a6162885c6515fc87c25cea61cd653</cites><orcidid>0000-0002-3486-5753</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10072-022-06014-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10072-022-06014-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35312879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yashan</creatorcontrib><creatorcontrib>Hu, Jiayi</creatorcontrib><creatorcontrib>Chen, Xiaofei</creatorcontrib><creatorcontrib>Wang, Song</creatorcontrib><creatorcontrib>Zhang, Chenyang</creatorcontrib><creatorcontrib>Hu, Junjun</creatorcontrib><creatorcontrib>Guo, Dingjie</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><title>Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis</title><title>Neurological sciences</title><addtitle>Neurol Sci</addtitle><addtitle>Neurol Sci</addtitle><description>Objective
Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases. This meta-analysis was performed to evaluate the diagnostic accuracy of RT-QuIC for Lewy body diseases.
Methods
This study followed the PRISMA statement. We searched six databases for relevant studies published until February 20, 2022. Meta-analysis was conducted using RevMan 5.3, Stata 17.0, and Meta-Disc 1.4. Subgroup analyses were performed to explore sources of heterogeneity.
Results
A total of 16 studies were included in this study. The pooled sensitivity and specificity were 0.91 (95%CI: 0.85–0.94) and 0.95 (95%CI: 0.90–0.97), respectively. The pooled positive and negative likelihood ratios were 17.16 (95% CI: 9.16–32.14) and 0.10 (95% CI: 0.06–0.17), respectively. The pooled diagnostic odds rate and area under the summary receiver operating characteristic curve were 171.16 (95% CI: 66.64–439.62) and 0.97 (95% CI: 0.96–0.99), respectively.
Conclusions
This study was the first meta-analysis on RT-QuIC for Lewy body diseases. RT-QuIC is a reliable and accurate method to diagnose Lewy body diseases.</description><subject>Lewy bodies</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Psychiatry</subject><subject>Review Article</subject><subject>Synuclein</subject><issn>1590-1874</issn><issn>1590-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1vFSEUhonR2A_9Ay4MiRs3WD6GAdyZRq3JTZoY3Uq4zKGhzkfLmamdf1-u96qJiy44kMNzXshDyCvB3wnOzRnuqmRc1tVy0bD7J-RYaMeZaox9ejgLa5ojcoJ4zXmFhHpOjpRWQlrjjsmPrxB6NucB6O0SfubxiuWxWyJ0NE7jHRTM00gDYlhpRhpiXEqYgaap0A38Wul26lbaZYSAgO9poAPMgYUx9CtmfEGepdAjvDzsp-T7p4_fzi_Y5vLzl_MPGxaV0TMDo110yaVOxi41Omlrt1vetE4lw5Mz0oRWtNJaHVstdIrWRKkj1G7sWq1Oydt97k2ZbhfA2Q8ZI_R9GGFa0Mu2EVYbw21F3_yHXk9Lqf_dUcY6a5VylZJ7KpYJsUDyNyUPoaxecL_z7vf2fbXvf9v393Xo9SF62Q7Q_R35o7sCag9gvRqvoPx7-5HYB5GOj_w</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Wang, Yashan</creator><creator>Hu, Jiayi</creator><creator>Chen, Xiaofei</creator><creator>Wang, Song</creator><creator>Zhang, Chenyang</creator><creator>Hu, Junjun</creator><creator>Guo, Dingjie</creator><creator>Liu, Xin</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3486-5753</orcidid></search><sort><creationdate>20220701</creationdate><title>Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis</title><author>Wang, Yashan ; Hu, Jiayi ; Chen, Xiaofei ; Wang, Song ; Zhang, Chenyang ; Hu, Junjun ; Guo, Dingjie ; Liu, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e759c9f9fd2cdf45f588bb04693f70f9727a6162885c6515fc87c25cea61cd653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Lewy bodies</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Psychiatry</topic><topic>Review Article</topic><topic>Synuclein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yashan</creatorcontrib><creatorcontrib>Hu, Jiayi</creatorcontrib><creatorcontrib>Chen, Xiaofei</creatorcontrib><creatorcontrib>Wang, Song</creatorcontrib><creatorcontrib>Zhang, Chenyang</creatorcontrib><creatorcontrib>Hu, Junjun</creatorcontrib><creatorcontrib>Guo, Dingjie</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yashan</au><au>Hu, Jiayi</au><au>Chen, Xiaofei</au><au>Wang, Song</au><au>Zhang, Chenyang</au><au>Hu, Junjun</au><au>Guo, Dingjie</au><au>Liu, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>43</volume><issue>7</issue><spage>4125</spage><epage>4132</epage><pages>4125-4132</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Objective
Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases. This meta-analysis was performed to evaluate the diagnostic accuracy of RT-QuIC for Lewy body diseases.
Methods
This study followed the PRISMA statement. We searched six databases for relevant studies published until February 20, 2022. Meta-analysis was conducted using RevMan 5.3, Stata 17.0, and Meta-Disc 1.4. Subgroup analyses were performed to explore sources of heterogeneity.
Results
A total of 16 studies were included in this study. The pooled sensitivity and specificity were 0.91 (95%CI: 0.85–0.94) and 0.95 (95%CI: 0.90–0.97), respectively. The pooled positive and negative likelihood ratios were 17.16 (95% CI: 9.16–32.14) and 0.10 (95% CI: 0.06–0.17), respectively. The pooled diagnostic odds rate and area under the summary receiver operating characteristic curve were 171.16 (95% CI: 66.64–439.62) and 0.97 (95% CI: 0.96–0.99), respectively.
Conclusions
This study was the first meta-analysis on RT-QuIC for Lewy body diseases. RT-QuIC is a reliable and accurate method to diagnose Lewy body diseases.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35312879</pmid><doi>10.1007/s10072-022-06014-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3486-5753</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Lewy bodies Medicine Medicine & Public Health Meta-analysis Neurology Neuroradiology Neurosciences Neurosurgery Psychiatry Review Article Synuclein |
| title | Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis |
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