Antioxidant role of selenium against maneb-induced cardiotoxicity in mice
The current study was conducted to assess the beneficial effect of selenium (Se) on maneb-induced cardiotoxicity and fatty acid alterations in adult mice. Swiss albino male mice were assigned into four experimental groups. The first group consisted of negative controls. The second group represented...
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| Veröffentlicht in: | Environmental science and pollution research international 2022-08, Vol.29 (36), p.54827-54841 |
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| creator | Sefi, Mediha Chaâbane, Mariem Bejaoui, Safa Elwej, Awatef Marrekchi, Rim Jamoussi, Kamel Gouiaa, Naourez Sellami, Tahia Boudawara El Cafsi, M’hamed Zeghal, Najiba |
| description | The current study was conducted to assess the beneficial effect of selenium (Se) on maneb-induced cardiotoxicity and fatty acid alterations in adult mice. Swiss albino male mice were assigned into four experimental groups. The first group consisted of negative controls. The second group represented the positive controls where mice received daily, via the diet, sodium selenite at a dose of 0.2 mg/kg. For the third group, mice were subjected to intraperitoneal injections of maneb (30 mg/kg BW). The fourth group (MB+Se) received daily the same dose of maneb as group 3 along with sodium selenite at the same dose as group 2. Mice exposure to maneb caused cardiotoxicity as indicated by an increase in malondialdehyde, hydrogen peroxide, and protein carbonyl levels, and an alteration of the antioxidant defense system (catalase, glutathione peroxidase, superoxide dismutase, glutathione, and vitamin C). Plasma lactate dehydrogenase activity and total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels increased, while high-density lipoprotein cholesterol level decreased. Results showed also a decrease in the amount of n-3 PUFA, docosahexaenoic, docosapentaenoic, and eicosapentaenoic acids. However, an increase in the levels of MUFA, cis-vaccenic, and palmitoleic acids was observed. Co-administration of Se restored the parameters indicated above to near control values. The histopathological findings confirmed the biochemical results. Selenium could be a useful and efficient agent against maneb-induced cardiotoxicity. |
| doi_str_mv | 10.1007/s11356-022-19497-0 |
| format | Article |
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Swiss albino male mice were assigned into four experimental groups. The first group consisted of negative controls. The second group represented the positive controls where mice received daily, via the diet, sodium selenite at a dose of 0.2 mg/kg. For the third group, mice were subjected to intraperitoneal injections of maneb (30 mg/kg BW). The fourth group (MB+Se) received daily the same dose of maneb as group 3 along with sodium selenite at the same dose as group 2. Mice exposure to maneb caused cardiotoxicity as indicated by an increase in malondialdehyde, hydrogen peroxide, and protein carbonyl levels, and an alteration of the antioxidant defense system (catalase, glutathione peroxidase, superoxide dismutase, glutathione, and vitamin C). Plasma lactate dehydrogenase activity and total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels increased, while high-density lipoprotein cholesterol level decreased. Results showed also a decrease in the amount of n-3 PUFA, docosahexaenoic, docosapentaenoic, and eicosapentaenoic acids. However, an increase in the levels of MUFA, cis-vaccenic, and palmitoleic acids was observed. Co-administration of Se restored the parameters indicated above to near control values. The histopathological findings confirmed the biochemical results. Selenium could be a useful and efficient agent against maneb-induced cardiotoxicity.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-022-19497-0</identifier><identifier>PMID: 35312919</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>adults ; albino ; antioxidant activity ; Antioxidants ; Aquatic Pollution ; Ascorbic acid ; Atmospheric Protection/Air Quality Control/Air Pollution ; Carbonyl compounds ; Carbonyls ; Cardiotoxicity ; Catalase ; Cholesterol ; Density ; diet ; docosahexaenoic acid ; Earth and Environmental Science ; Ecotoxicology ; eicosapentaenoic acid ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Fatty acids ; Glutathione ; Glutathione peroxidase ; High density lipoprotein ; high density lipoprotein cholesterol ; histopathology ; Hydrogen peroxide ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; low density lipoprotein cholesterol ; males ; malondialdehyde ; maneb ; omega-3 fatty acids ; Oxidative stress ; Peroxidase ; Polyunsaturated fatty acids ; Research Article ; Selenites ; Selenium ; Sodium ; Sodium selenite ; Superoxide dismutase ; triacylglycerols ; Triglycerides ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2022-08, Vol.29 (36), p.54827-54841</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-f7b5521aa97c0c1e351e8668511d8700c17b24ba56d0b1c5ff26f67af9e413de3</cites><orcidid>0000-0002-8624-5417</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-022-19497-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-022-19497-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35312919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sefi, Mediha</creatorcontrib><creatorcontrib>Chaâbane, Mariem</creatorcontrib><creatorcontrib>Bejaoui, Safa</creatorcontrib><creatorcontrib>Elwej, Awatef</creatorcontrib><creatorcontrib>Marrekchi, Rim</creatorcontrib><creatorcontrib>Jamoussi, Kamel</creatorcontrib><creatorcontrib>Gouiaa, Naourez</creatorcontrib><creatorcontrib>Sellami, Tahia Boudawara</creatorcontrib><creatorcontrib>El Cafsi, M’hamed</creatorcontrib><creatorcontrib>Zeghal, Najiba</creatorcontrib><title>Antioxidant role of selenium against maneb-induced cardiotoxicity in mice</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>The current study was conducted to assess the beneficial effect of selenium (Se) on maneb-induced cardiotoxicity and fatty acid alterations in adult mice. Swiss albino male mice were assigned into four experimental groups. The first group consisted of negative controls. The second group represented the positive controls where mice received daily, via the diet, sodium selenite at a dose of 0.2 mg/kg. For the third group, mice were subjected to intraperitoneal injections of maneb (30 mg/kg BW). The fourth group (MB+Se) received daily the same dose of maneb as group 3 along with sodium selenite at the same dose as group 2. Mice exposure to maneb caused cardiotoxicity as indicated by an increase in malondialdehyde, hydrogen peroxide, and protein carbonyl levels, and an alteration of the antioxidant defense system (catalase, glutathione peroxidase, superoxide dismutase, glutathione, and vitamin C). Plasma lactate dehydrogenase activity and total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels increased, while high-density lipoprotein cholesterol level decreased. Results showed also a decrease in the amount of n-3 PUFA, docosahexaenoic, docosapentaenoic, and eicosapentaenoic acids. However, an increase in the levels of MUFA, cis-vaccenic, and palmitoleic acids was observed. Co-administration of Se restored the parameters indicated above to near control values. The histopathological findings confirmed the biochemical results. Selenium could be a useful and efficient agent against maneb-induced cardiotoxicity.</description><subject>adults</subject><subject>albino</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Aquatic Pollution</subject><subject>Ascorbic acid</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Carbonyl compounds</subject><subject>Carbonyls</subject><subject>Cardiotoxicity</subject><subject>Catalase</subject><subject>Cholesterol</subject><subject>Density</subject><subject>diet</subject><subject>docosahexaenoic acid</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>eicosapentaenoic acid</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Fatty acids</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>High density lipoprotein</subject><subject>high density lipoprotein cholesterol</subject><subject>histopathology</subject><subject>Hydrogen peroxide</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>low density lipoprotein cholesterol</subject><subject>males</subject><subject>malondialdehyde</subject><subject>maneb</subject><subject>omega-3 fatty acids</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Polyunsaturated fatty acids</subject><subject>Research Article</subject><subject>Selenites</subject><subject>Selenium</subject><subject>Sodium</subject><subject>Sodium selenite</subject><subject>Superoxide dismutase</subject><subject>triacylglycerols</subject><subject>Triglycerides</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution 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role of selenium against maneb-induced cardiotoxicity in mice</title><author>Sefi, Mediha ; Chaâbane, Mariem ; Bejaoui, Safa ; Elwej, Awatef ; Marrekchi, Rim ; Jamoussi, Kamel ; Gouiaa, Naourez ; Sellami, Tahia Boudawara ; El Cafsi, M’hamed ; Zeghal, Najiba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-f7b5521aa97c0c1e351e8668511d8700c17b24ba56d0b1c5ff26f67af9e413de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>adults</topic><topic>albino</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Aquatic Pollution</topic><topic>Ascorbic acid</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Carbonyl compounds</topic><topic>Carbonyls</topic><topic>Cardiotoxicity</topic><topic>Catalase</topic><topic>Cholesterol</topic><topic>Density</topic><topic>diet</topic><topic>docosahexaenoic acid</topic><topic>Earth and 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Int</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>29</volume><issue>36</issue><spage>54827</spage><epage>54841</epage><pages>54827-54841</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>The current study was conducted to assess the beneficial effect of selenium (Se) on maneb-induced cardiotoxicity and fatty acid alterations in adult mice. Swiss albino male mice were assigned into four experimental groups. The first group consisted of negative controls. The second group represented the positive controls where mice received daily, via the diet, sodium selenite at a dose of 0.2 mg/kg. For the third group, mice were subjected to intraperitoneal injections of maneb (30 mg/kg BW). The fourth group (MB+Se) received daily the same dose of maneb as group 3 along with sodium selenite at the same dose as group 2. Mice exposure to maneb caused cardiotoxicity as indicated by an increase in malondialdehyde, hydrogen peroxide, and protein carbonyl levels, and an alteration of the antioxidant defense system (catalase, glutathione peroxidase, superoxide dismutase, glutathione, and vitamin C). Plasma lactate dehydrogenase activity and total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels increased, while high-density lipoprotein cholesterol level decreased. Results showed also a decrease in the amount of n-3 PUFA, docosahexaenoic, docosapentaenoic, and eicosapentaenoic acids. However, an increase in the levels of MUFA, cis-vaccenic, and palmitoleic acids was observed. Co-administration of Se restored the parameters indicated above to near control values. The histopathological findings confirmed the biochemical results. Selenium could be a useful and efficient agent against maneb-induced cardiotoxicity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35312919</pmid><doi>10.1007/s11356-022-19497-0</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-8624-5417</orcidid></addata></record> |
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| subjects | adults albino antioxidant activity Antioxidants Aquatic Pollution Ascorbic acid Atmospheric Protection/Air Quality Control/Air Pollution Carbonyl compounds Carbonyls Cardiotoxicity Catalase Cholesterol Density diet docosahexaenoic acid Earth and Environmental Science Ecotoxicology eicosapentaenoic acid Environment Environmental Chemistry Environmental Health Environmental science Fatty acids Glutathione Glutathione peroxidase High density lipoprotein high density lipoprotein cholesterol histopathology Hydrogen peroxide L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid low density lipoprotein cholesterol males malondialdehyde maneb omega-3 fatty acids Oxidative stress Peroxidase Polyunsaturated fatty acids Research Article Selenites Selenium Sodium Sodium selenite Superoxide dismutase triacylglycerols Triglycerides Waste Water Technology Water Management Water Pollution Control |
| title | Antioxidant role of selenium against maneb-induced cardiotoxicity in mice |
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