Performance of a simplified scoring system for risk stratification in oral cancer and oral potentially malignant disorders screening

Background Impact and efficiency of oral cancer and oral potentially malignant disorders screening are most realized in “at‐risk” individuals. However, tools that can provide essential knowledge on individuals' risks are not applied in risk‐based screening. This study aims to optimize a simplif...

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Veröffentlicht in:Journal of oral pathology & medicine 2022-05, Vol.51 (5), p.464-473
Hauptverfasser: Adeoye, John, Sakeen Alkandari, Abdulrahman, Tan, Jia Yan, Wang, Weilan, Zhu, Wang‐Yong, Thomson, Peter, Zheng, Li‐Wu, Choi, Siu‐Wai, Su, Yu‐Xiong
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container_end_page 473
container_issue 5
container_start_page 464
container_title Journal of oral pathology & medicine
container_volume 51
creator Adeoye, John
Sakeen Alkandari, Abdulrahman
Tan, Jia Yan
Wang, Weilan
Zhu, Wang‐Yong
Thomson, Peter
Zheng, Li‐Wu
Choi, Siu‐Wai
Su, Yu‐Xiong
description Background Impact and efficiency of oral cancer and oral potentially malignant disorders screening are most realized in “at‐risk” individuals. However, tools that can provide essential knowledge on individuals' risks are not applied in risk‐based screening. This study aims to optimize a simplified risk scoring system for risk stratification in organized oral cancer and oral potentially malignant disorders screening. Methods Participants were invited to attend a community‐based oral cancer and oral potentially malignant disorders screening program in Hong Kong. Visual oral examination was performed for all attendees and information on sociodemographic characteristics as well as habitual, lifestyle, familial, and comorbidity risk factors were obtained. Individuals' status of those found to have suspicious lesions following biopsy and histopathology were classified as positive/negative and this outcome was used in a multiple logistic regression analysis with variables collected during screening. Odds ratio weightings were then used to develop a simplified risk scoring system which was validated in an external cohort. Results Of 979 participants, 4.5% had positive status following confirmatory diagnosis. A 12‐variable simplified risk scoring system with weightings was generated with an AUC, sensitivity, and specificity of 0.82, 0.71, and 0.78 for delineating high‐risk cases. Further optimization on the validation cohort of 491 participants yielded a sensitivity and specificity of 0.75 and 0.87 respectively. Conclusions The simplified risk scoring system was able to stratify oral cancer and oral potentially malignant disorders risk with satisfactory sensitivity and specificity and can be applied in risk‐based disease screening.
doi_str_mv 10.1111/jop.13293
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However, tools that can provide essential knowledge on individuals' risks are not applied in risk‐based screening. This study aims to optimize a simplified risk scoring system for risk stratification in organized oral cancer and oral potentially malignant disorders screening. Methods Participants were invited to attend a community‐based oral cancer and oral potentially malignant disorders screening program in Hong Kong. Visual oral examination was performed for all attendees and information on sociodemographic characteristics as well as habitual, lifestyle, familial, and comorbidity risk factors were obtained. Individuals' status of those found to have suspicious lesions following biopsy and histopathology were classified as positive/negative and this outcome was used in a multiple logistic regression analysis with variables collected during screening. Odds ratio weightings were then used to develop a simplified risk scoring system which was validated in an external cohort. Results Of 979 participants, 4.5% had positive status following confirmatory diagnosis. A 12‐variable simplified risk scoring system with weightings was generated with an AUC, sensitivity, and specificity of 0.82, 0.71, and 0.78 for delineating high‐risk cases. Further optimization on the validation cohort of 491 participants yielded a sensitivity and specificity of 0.75 and 0.87 respectively. Conclusions The simplified risk scoring system was able to stratify oral cancer and oral potentially malignant disorders risk with satisfactory sensitivity and specificity and can be applied in risk‐based disease screening.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.13293</identifier><identifier>PMID: 35312123</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Biopsy ; Medical screening ; Oral cancer ; oral potentially malignant disorders ; Risk factors ; risk model ; screening</subject><ispartof>Journal of oral pathology &amp; medicine, 2022-05, Vol.51 (5), p.464-473</ispartof><rights>2022 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2022 John Wiley &amp; Sons A/S. 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However, tools that can provide essential knowledge on individuals' risks are not applied in risk‐based screening. This study aims to optimize a simplified risk scoring system for risk stratification in organized oral cancer and oral potentially malignant disorders screening. Methods Participants were invited to attend a community‐based oral cancer and oral potentially malignant disorders screening program in Hong Kong. Visual oral examination was performed for all attendees and information on sociodemographic characteristics as well as habitual, lifestyle, familial, and comorbidity risk factors were obtained. Individuals' status of those found to have suspicious lesions following biopsy and histopathology were classified as positive/negative and this outcome was used in a multiple logistic regression analysis with variables collected during screening. Odds ratio weightings were then used to develop a simplified risk scoring system which was validated in an external cohort. Results Of 979 participants, 4.5% had positive status following confirmatory diagnosis. A 12‐variable simplified risk scoring system with weightings was generated with an AUC, sensitivity, and specificity of 0.82, 0.71, and 0.78 for delineating high‐risk cases. Further optimization on the validation cohort of 491 participants yielded a sensitivity and specificity of 0.75 and 0.87 respectively. Conclusions The simplified risk scoring system was able to stratify oral cancer and oral potentially malignant disorders risk with satisfactory sensitivity and specificity and can be applied in risk‐based disease screening.</description><subject>Biopsy</subject><subject>Medical screening</subject><subject>Oral cancer</subject><subject>oral potentially malignant disorders</subject><subject>Risk factors</subject><subject>risk model</subject><subject>screening</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kcFO3DAURa0KBNOBRX8AWWLTLsL4xYmTLNGoLUVIsJh95DjPyINjBzsjNHs-vB4CLCr1Lfxk6fj4SpeQb8CuIM1q68cr4HnDv5AFCMYyVkFxRBasYUWWl5Cfkq8xbhmDihdwQk55ySGHnC_I6wMG7cMgnULqNZU0mmG0RhvsaVQ-GPdI4z5OONDE0WDiE41TkFNCVDq9o8ZRH6Sl6iAJVLp-vo9-QjcZae2eDtKaRyfdRHsTfegxxKQPiC59cEaOtbQRz9_3kmx-_dysb7K7-99_1td3mUqBedbVJaKUTVP3Ra1yDrrjtUJRCFFCV5Z1x3SpsO-k1oCi6hrVi4o3Wsu6UoovyfdZOwb_vMM4tYOJCq2VDv0utrkooATRiCKhl_-gW78LLoVLVAVQFZDMS_JjplTwMQbU7RjMIMO-BdYemkmvxvatmcRevBt33YD9J_lRRQJWM_BiLO7_b2pv7x9m5V-yBJr_</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Adeoye, John</creator><creator>Sakeen Alkandari, Abdulrahman</creator><creator>Tan, Jia Yan</creator><creator>Wang, Weilan</creator><creator>Zhu, Wang‐Yong</creator><creator>Thomson, Peter</creator><creator>Zheng, Li‐Wu</creator><creator>Choi, Siu‐Wai</creator><creator>Su, Yu‐Xiong</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202205</creationdate><title>Performance of a simplified scoring system for risk stratification in oral cancer and oral potentially malignant disorders screening</title><author>Adeoye, John ; Sakeen Alkandari, Abdulrahman ; Tan, Jia Yan ; Wang, Weilan ; Zhu, Wang‐Yong ; Thomson, Peter ; Zheng, Li‐Wu ; Choi, Siu‐Wai ; Su, Yu‐Xiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-b85eeaa998d48c231fb38ce646651b558b0f5cedbaff1e67b9cd6739ffa87cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biopsy</topic><topic>Medical screening</topic><topic>Oral cancer</topic><topic>oral potentially malignant disorders</topic><topic>Risk factors</topic><topic>risk model</topic><topic>screening</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adeoye, John</creatorcontrib><creatorcontrib>Sakeen Alkandari, Abdulrahman</creatorcontrib><creatorcontrib>Tan, Jia Yan</creatorcontrib><creatorcontrib>Wang, Weilan</creatorcontrib><creatorcontrib>Zhu, Wang‐Yong</creatorcontrib><creatorcontrib>Thomson, Peter</creatorcontrib><creatorcontrib>Zheng, Li‐Wu</creatorcontrib><creatorcontrib>Choi, Siu‐Wai</creatorcontrib><creatorcontrib>Su, Yu‐Xiong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology &amp; medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adeoye, John</au><au>Sakeen Alkandari, Abdulrahman</au><au>Tan, Jia Yan</au><au>Wang, Weilan</au><au>Zhu, Wang‐Yong</au><au>Thomson, Peter</au><au>Zheng, Li‐Wu</au><au>Choi, Siu‐Wai</au><au>Su, Yu‐Xiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance of a simplified scoring system for risk stratification in oral cancer and oral potentially malignant disorders screening</atitle><jtitle>Journal of oral pathology &amp; medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2022-05</date><risdate>2022</risdate><volume>51</volume><issue>5</issue><spage>464</spage><epage>473</epage><pages>464-473</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background Impact and efficiency of oral cancer and oral potentially malignant disorders screening are most realized in “at‐risk” individuals. However, tools that can provide essential knowledge on individuals' risks are not applied in risk‐based screening. This study aims to optimize a simplified risk scoring system for risk stratification in organized oral cancer and oral potentially malignant disorders screening. Methods Participants were invited to attend a community‐based oral cancer and oral potentially malignant disorders screening program in Hong Kong. Visual oral examination was performed for all attendees and information on sociodemographic characteristics as well as habitual, lifestyle, familial, and comorbidity risk factors were obtained. Individuals' status of those found to have suspicious lesions following biopsy and histopathology were classified as positive/negative and this outcome was used in a multiple logistic regression analysis with variables collected during screening. Odds ratio weightings were then used to develop a simplified risk scoring system which was validated in an external cohort. Results Of 979 participants, 4.5% had positive status following confirmatory diagnosis. A 12‐variable simplified risk scoring system with weightings was generated with an AUC, sensitivity, and specificity of 0.82, 0.71, and 0.78 for delineating high‐risk cases. Further optimization on the validation cohort of 491 participants yielded a sensitivity and specificity of 0.75 and 0.87 respectively. Conclusions The simplified risk scoring system was able to stratify oral cancer and oral potentially malignant disorders risk with satisfactory sensitivity and specificity and can be applied in risk‐based disease screening.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35312123</pmid><doi>10.1111/jop.13293</doi><tpages>10</tpages></addata></record>
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subjects Biopsy
Medical screening
Oral cancer
oral potentially malignant disorders
Risk factors
risk model
screening
title Performance of a simplified scoring system for risk stratification in oral cancer and oral potentially malignant disorders screening
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