Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa

To investigate the effect of stanniocalcin-1 (STC-1), a secreted polypeptide exhibiting multiple functions in cell survival and death, on photoreceptor degeneration in a porcine model of retinitis pigmentosa (RP). P23H transgenic pigs (TG P23H) and wild-type hybrid littermates were obtained from the...

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Veröffentlicht in:	American journal of ophthalmology 2022-07, Vol.239, p.230-243
Hauptverfasser:	Rosa, Robert H., Xie, Wankun, Zhao, Min, Tsai, Shu-Huai, Roddy, Gavin W., Su, Maxwell G., Potts, Luke B., Hein, Travis W., Kuo, Lih
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Angiogenesis Animals Apoptosis Gene expression Hogs Inflammation Mutation Optics Ovaries Oxidative stress Photoreceptors Proteins Tomography
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