Role of Preoperational Imaging Traits for Guiding Treatment in Single ≤ 5 cm Hepatocellular Carcinoma
Background Imaging traits including nonsmooth tumor margins, internal arteries, peritumoral enhancement, and absence of hypodense halos can reflect tumor aggressiveness preoperatively and may affect treatment selection. This study aimed to explore the role of these four imaging traits in treatment s...
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| Veröffentlicht in: | Annals of surgical oncology 2022-08, Vol.29 (8), p.5144-5153 |
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| container_title | Annals of surgical oncology |
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| creator | Wei, Mengchao Lin, Manxia Zhong, Xian Dai, Zihao Shen, Shunli Li, Shaoqiang Peng, Zhenwei Kuang, Ming |
| description | Background
Imaging traits including nonsmooth tumor margins, internal arteries, peritumoral enhancement, and absence of hypodense halos can reflect tumor aggressiveness preoperatively and may affect treatment selection. This study aimed to explore the role of these four imaging traits in treatment selection between surgical resection (SR) and radiofrequency ablation (RFA) for patients with single ≤ 5 cm hepatocellular carcinoma (HCC).
Patients and Methods
Three hundred eight-one patients with single ≤ 5 cm HCC who underwent SR (
n
= 202) or RFA (
n
= 179) in the First Affiliated Hospital of Sun Yat-sen University from April 2010 to December 2019 were retrospectively enrolled. The efficacy of SR and RFA in patients with the imaging traits that significantly influenced recurrence-free survival (RFS) or overall survival (OS) was compared and analyzed.
Results
Multivariable Cox regression analysis identified that having internal arteries (
P
= 0.001) was an independent influencing factor for RFS, while internal arteries (
P
= 0.005) and peritumoral enhancement (
P
= 0.001) were independent influencing factors for OS. In patients with internal arteries, subgroup analysis based on tumor size demonstrated that both RFS and OS of SR were superior to those of RFA in patients with 3–5 cm HCC (RFS,
P
= 0.023; OS,
P
= 0.015). In patients with peritumoral enhancement, both RFS and OS of SR were superior to those of RFA (RFS,
P
= 0.019; OS,
P
= 0.042).
Conclusion
SR may be associated with improved survival compared with RFA in patients with single 3–5 cm HCC having internal arteries and patients with single ≤ 5 cm HCC having peritumoral enhancement. |
| doi_str_mv | 10.1245/s10434-022-11344-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2641508507</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2682578138</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-57c3fe1bef0f0ea0f09d0e618bab73777ba21ebc254aa27cd3030b95035140233</originalsourceid><addsrcrecordid>eNp9kU1OHDEQha2IKBCSC7BAlrJh00n5r92zjEb8SUhECVlb1T3VI6Pu9sTuXnAEbsGCk3AUThJPGojEgo3LevX5uezH2IGAr0Jq8y0J0EoXIGUhhNK6UO_YnjBZ0mUldvIeyqpYyNLsso8pXQMIq8B8YLvKKLAVmD3mf4aOeGj5j0hhQxFHHwbs-HmPaz-s-VVEPybehshPJ7-aJcKxp2HkfuC_spINHm_vH-7Mw13T8zPa4Bga6rqpw8iXGBs_hB4_sfctdok-P9V99vvk-Gp5Vlxcnp4vv18UjbJmLIxtVEuiphZaIMzLYgVUiqrG2iprbY1SUN1IoxGlbVYKFNQLA8oIDVKpfXY0-25i-DNRGl3v03YcHChMyclSCwOVAZvRL6_Q6zDF_PwtVUljK6GqTMmZamJIKVLrNtH3GG-cALcNws1BuByE-xeE205x-GQ91T2tXo48_3wG1Ayk3BrWFP_f_YbtXw4plSc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2682578138</pqid></control><display><type>article</type><title>Role of Preoperational Imaging Traits for Guiding Treatment in Single ≤ 5 cm Hepatocellular Carcinoma</title><source>SpringerLink Journals - AutoHoldings</source><creator>Wei, Mengchao ; Lin, Manxia ; Zhong, Xian ; Dai, Zihao ; Shen, Shunli ; Li, Shaoqiang ; Peng, Zhenwei ; Kuang, Ming</creator><creatorcontrib>Wei, Mengchao ; Lin, Manxia ; Zhong, Xian ; Dai, Zihao ; Shen, Shunli ; Li, Shaoqiang ; Peng, Zhenwei ; Kuang, Ming</creatorcontrib><description>Background
Imaging traits including nonsmooth tumor margins, internal arteries, peritumoral enhancement, and absence of hypodense halos can reflect tumor aggressiveness preoperatively and may affect treatment selection. This study aimed to explore the role of these four imaging traits in treatment selection between surgical resection (SR) and radiofrequency ablation (RFA) for patients with single ≤ 5 cm hepatocellular carcinoma (HCC).
Patients and Methods
Three hundred eight-one patients with single ≤ 5 cm HCC who underwent SR (
n
= 202) or RFA (
n
= 179) in the First Affiliated Hospital of Sun Yat-sen University from April 2010 to December 2019 were retrospectively enrolled. The efficacy of SR and RFA in patients with the imaging traits that significantly influenced recurrence-free survival (RFS) or overall survival (OS) was compared and analyzed.
Results
Multivariable Cox regression analysis identified that having internal arteries (
P
= 0.001) was an independent influencing factor for RFS, while internal arteries (
P
= 0.005) and peritumoral enhancement (
P
= 0.001) were independent influencing factors for OS. In patients with internal arteries, subgroup analysis based on tumor size demonstrated that both RFS and OS of SR were superior to those of RFA in patients with 3–5 cm HCC (RFS,
P
= 0.023; OS,
P
= 0.015). In patients with peritumoral enhancement, both RFS and OS of SR were superior to those of RFA (RFS,
P
= 0.019; OS,
P
= 0.042).
Conclusion
SR may be associated with improved survival compared with RFA in patients with single 3–5 cm HCC having internal arteries and patients with single ≤ 5 cm HCC having peritumoral enhancement.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-022-11344-3</identifier><identifier>PMID: 35307805</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Arteries ; Hepatobiliary Tumors ; Hepatocellular carcinoma ; Liver cancer ; Medicine ; Medicine & Public Health ; Oncology ; Patients ; Surgery ; Surgical Oncology ; Survival ; Tumors</subject><ispartof>Annals of surgical oncology, 2022-08, Vol.29 (8), p.5144-5153</ispartof><rights>Society of Surgical Oncology 2022</rights><rights>2022. Society of Surgical Oncology.</rights><rights>Society of Surgical Oncology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-57c3fe1bef0f0ea0f09d0e618bab73777ba21ebc254aa27cd3030b95035140233</citedby><cites>FETCH-LOGICAL-c375t-57c3fe1bef0f0ea0f09d0e618bab73777ba21ebc254aa27cd3030b95035140233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-022-11344-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-022-11344-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35307805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Mengchao</creatorcontrib><creatorcontrib>Lin, Manxia</creatorcontrib><creatorcontrib>Zhong, Xian</creatorcontrib><creatorcontrib>Dai, Zihao</creatorcontrib><creatorcontrib>Shen, Shunli</creatorcontrib><creatorcontrib>Li, Shaoqiang</creatorcontrib><creatorcontrib>Peng, Zhenwei</creatorcontrib><creatorcontrib>Kuang, Ming</creatorcontrib><title>Role of Preoperational Imaging Traits for Guiding Treatment in Single ≤ 5 cm Hepatocellular Carcinoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Imaging traits including nonsmooth tumor margins, internal arteries, peritumoral enhancement, and absence of hypodense halos can reflect tumor aggressiveness preoperatively and may affect treatment selection. This study aimed to explore the role of these four imaging traits in treatment selection between surgical resection (SR) and radiofrequency ablation (RFA) for patients with single ≤ 5 cm hepatocellular carcinoma (HCC).
Patients and Methods
Three hundred eight-one patients with single ≤ 5 cm HCC who underwent SR (
n
= 202) or RFA (
n
= 179) in the First Affiliated Hospital of Sun Yat-sen University from April 2010 to December 2019 were retrospectively enrolled. The efficacy of SR and RFA in patients with the imaging traits that significantly influenced recurrence-free survival (RFS) or overall survival (OS) was compared and analyzed.
Results
Multivariable Cox regression analysis identified that having internal arteries (
P
= 0.001) was an independent influencing factor for RFS, while internal arteries (
P
= 0.005) and peritumoral enhancement (
P
= 0.001) were independent influencing factors for OS. In patients with internal arteries, subgroup analysis based on tumor size demonstrated that both RFS and OS of SR were superior to those of RFA in patients with 3–5 cm HCC (RFS,
P
= 0.023; OS,
P
= 0.015). In patients with peritumoral enhancement, both RFS and OS of SR were superior to those of RFA (RFS,
P
= 0.019; OS,
P
= 0.042).
Conclusion
SR may be associated with improved survival compared with RFA in patients with single 3–5 cm HCC having internal arteries and patients with single ≤ 5 cm HCC having peritumoral enhancement.</description><subject>Arteries</subject><subject>Hepatobiliary Tumors</subject><subject>Hepatocellular carcinoma</subject><subject>Liver cancer</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Patients</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Tumors</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1OHDEQha2IKBCSC7BAlrJh00n5r92zjEb8SUhECVlb1T3VI6Pu9sTuXnAEbsGCk3AUThJPGojEgo3LevX5uezH2IGAr0Jq8y0J0EoXIGUhhNK6UO_YnjBZ0mUldvIeyqpYyNLsso8pXQMIq8B8YLvKKLAVmD3mf4aOeGj5j0hhQxFHHwbs-HmPaz-s-VVEPybehshPJ7-aJcKxp2HkfuC_spINHm_vH-7Mw13T8zPa4Bga6rqpw8iXGBs_hB4_sfctdok-P9V99vvk-Gp5Vlxcnp4vv18UjbJmLIxtVEuiphZaIMzLYgVUiqrG2iprbY1SUN1IoxGlbVYKFNQLA8oIDVKpfXY0-25i-DNRGl3v03YcHChMyclSCwOVAZvRL6_Q6zDF_PwtVUljK6GqTMmZamJIKVLrNtH3GG-cALcNws1BuByE-xeE205x-GQ91T2tXo48_3wG1Ayk3BrWFP_f_YbtXw4plSc</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Wei, Mengchao</creator><creator>Lin, Manxia</creator><creator>Zhong, Xian</creator><creator>Dai, Zihao</creator><creator>Shen, Shunli</creator><creator>Li, Shaoqiang</creator><creator>Peng, Zhenwei</creator><creator>Kuang, Ming</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220801</creationdate><title>Role of Preoperational Imaging Traits for Guiding Treatment in Single ≤ 5 cm Hepatocellular Carcinoma</title><author>Wei, Mengchao ; Lin, Manxia ; Zhong, Xian ; Dai, Zihao ; Shen, Shunli ; Li, Shaoqiang ; Peng, Zhenwei ; Kuang, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-57c3fe1bef0f0ea0f09d0e618bab73777ba21ebc254aa27cd3030b95035140233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arteries</topic><topic>Hepatobiliary Tumors</topic><topic>Hepatocellular carcinoma</topic><topic>Liver cancer</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Patients</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Mengchao</creatorcontrib><creatorcontrib>Lin, Manxia</creatorcontrib><creatorcontrib>Zhong, Xian</creatorcontrib><creatorcontrib>Dai, Zihao</creatorcontrib><creatorcontrib>Shen, Shunli</creatorcontrib><creatorcontrib>Li, Shaoqiang</creatorcontrib><creatorcontrib>Peng, Zhenwei</creatorcontrib><creatorcontrib>Kuang, Ming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Mengchao</au><au>Lin, Manxia</au><au>Zhong, Xian</au><au>Dai, Zihao</au><au>Shen, Shunli</au><au>Li, Shaoqiang</au><au>Peng, Zhenwei</au><au>Kuang, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Preoperational Imaging Traits for Guiding Treatment in Single ≤ 5 cm Hepatocellular Carcinoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>29</volume><issue>8</issue><spage>5144</spage><epage>5153</epage><pages>5144-5153</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Imaging traits including nonsmooth tumor margins, internal arteries, peritumoral enhancement, and absence of hypodense halos can reflect tumor aggressiveness preoperatively and may affect treatment selection. This study aimed to explore the role of these four imaging traits in treatment selection between surgical resection (SR) and radiofrequency ablation (RFA) for patients with single ≤ 5 cm hepatocellular carcinoma (HCC).
Patients and Methods
Three hundred eight-one patients with single ≤ 5 cm HCC who underwent SR (
n
= 202) or RFA (
n
= 179) in the First Affiliated Hospital of Sun Yat-sen University from April 2010 to December 2019 were retrospectively enrolled. The efficacy of SR and RFA in patients with the imaging traits that significantly influenced recurrence-free survival (RFS) or overall survival (OS) was compared and analyzed.
Results
Multivariable Cox regression analysis identified that having internal arteries (
P
= 0.001) was an independent influencing factor for RFS, while internal arteries (
P
= 0.005) and peritumoral enhancement (
P
= 0.001) were independent influencing factors for OS. In patients with internal arteries, subgroup analysis based on tumor size demonstrated that both RFS and OS of SR were superior to those of RFA in patients with 3–5 cm HCC (RFS,
P
= 0.023; OS,
P
= 0.015). In patients with peritumoral enhancement, both RFS and OS of SR were superior to those of RFA (RFS,
P
= 0.019; OS,
P
= 0.042).
Conclusion
SR may be associated with improved survival compared with RFA in patients with single 3–5 cm HCC having internal arteries and patients with single ≤ 5 cm HCC having peritumoral enhancement.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35307805</pmid><doi>10.1245/s10434-022-11344-3</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2022-08, Vol.29 (8), p.5144-5153 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2641508507 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Arteries Hepatobiliary Tumors Hepatocellular carcinoma Liver cancer Medicine Medicine & Public Health Oncology Patients Surgery Surgical Oncology Survival Tumors |
| title | Role of Preoperational Imaging Traits for Guiding Treatment in Single ≤ 5 cm Hepatocellular Carcinoma |
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