Biophysical characterization of the interaction of Atg8 with a disordered region of Nup159 involved in selective autophagy of the nuclear pore complex

A functional proteome in the cell is maintained by coordinate regulation of biogenesis, folding, and degradation of cellular proteins. Although the degradation pathways have been extensively characterized for various substrates, it remains elusive how large multiprotein complexes are selectively deg...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-05, Vol.604, p.172-178
Hauptverfasser:	Kim, RyeongHyeon, Koh, Junseock
Format:	Artikel
Sprache:	eng
Schlagworte:	Atg8 Autophagy - physiology Autophagy-Related Protein 8 Family - metabolism Coupled conformational change Heat capacity change Intrinsically disordered region Nuclear Pore - metabolism Nuclear Pore Complex Proteins - metabolism Nucleoporin Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Selective autophagy
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