CD30+ Lymphoproliferative Disorders as Potential Candidates for CD30-Targeted Therapies

In the early 1980s, a monoclonal antibody termed Ki-1 was developed against a cell line derived from a patient with Hodgkin lymphoma. This antibody detected a limited number of benign activated lymphocytes in lymphoid tissue, whereas in Hodgkin lymphoma it appeared to be nearly specific for Reed-Ste...

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Veröffentlicht in:	Archives of pathology & laboratory medicine (1976) 2022-04, Vol.146 (4), p.415-432
Hauptverfasser:	Schwarting, Roland, Behling, Eric, Allen, Ashleigh, Arguello-Guerra, Vivian, Budak-Alpdogan, Tulin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antineoplastic Agents - therapeutic use Autografts CD30 antigen Cell cycle Chemotherapy Epitopes Epstein-Barr virus Follicles Formaldehyde Gene rearrangement Germinal centers Hematologic Neoplasms Hodgkin Disease Humans Immunoconjugates - therapeutic use Immunoproliferative diseases Ki-1 Antigen - metabolism Laboratories Ligands Lymphatic diseases Lymphocytes Lymphocytes B Lymphoid tissue Lymphoma Lymphoma, Large-Cell, Anaplastic - drug therapy Lymphoma, Large-Cell, Anaplastic - pathology Monoclonal antibodies Morphology Paraffin Stem cell transplantation Tumor necrosis factor-TNF Tumors
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