The hypoxia-inducible factor prolyl hydroxylase inhibitor FG4592 promotes natriuresis through upregulation of COX2 in the renal medulla

The renal medulla is a key site for the regulation of renal sodium excretion. However, the molecular mechanism remains unclear. Cyclooxygenase 2 (COX2) is specifically expressed in the renal medulla and contributes to the maintenance of the electrolyte/water balance in the body. Hypoxia-inducible fa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Hypertension research 2022-05, Vol.45 (5), p.814-823
Hauptverfasser:	Guan, Nan, Zhang, Min, Gong, Wei-Yuan, Mao, Xiao-Yi, Yang, Si-Si, Hao, Chuan-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclooxygenase 2 - metabolism Homeostasis Hypertension Hypoxia Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kidneys Mice Natriuresis Prolyl-Hydroxylase Inhibitors - pharmacology Sodium Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!