Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice

Background Plant-derived phytochemicals have been reported to exert anticancer activity. This study investigated the antitumor role of silymarin ( Silybum marianum ) (SMN) and its molecular targets in Ehrlich solid tumor xenografts in vivo. Methods and results Female Swiss albino mice were divided i...

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Veröffentlicht in:	Molecular biology reports 2022-06, Vol.49 (6), p.4659-4671
Hauptverfasser:	Amer, Maggie E., Amer, Maher A., Othman, Azza I., Elsayed, Doaa A., El-Missiry, Mohamed Amr, Ammar, Omar A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal Anatomy Animal Biochemistry Antioxidants Antitumor activity Apoptosis Biomedical and Life Sciences Body mass Cancer Cell cycle Cell death Cell density Cell division Cyclin D1 Degeneration E-cadherin Histology Life Sciences Metastases Metastasis Mitochondria Morphology NF-κB protein Original Article Oxidative stress Plants Proliferating cell nuclear antigen Silymarin Solid tumors Tumors Vascular endothelial growth factor Xenografts
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