EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis
The prevention and management of bleeding and thrombosis in patients with cirrhosis poses several difficult clinical questions. These Clinical Practice Guidelines have been developed to provide practical guidance on debated topics, including current views on haemostasis in liver disease, controversy...
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Veröffentlicht in: | Journal of hepatology 2022-05, Vol.76 (5), p.1151-1184 |
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container_title | Journal of hepatology |
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creator | Villa, Erica Bianchini, Marcello Blasi, Annabel Denys, Alban Giannini, Edoardo G. de Gottardi, Andrea Lisman, Ton de Raucourt, Emmanuelle Ripoll, Cristina Rautou, Pierre-Emmanuel |
description | The prevention and management of bleeding and thrombosis in patients with cirrhosis poses several difficult clinical questions. These Clinical Practice Guidelines have been developed to provide practical guidance on debated topics, including current views on haemostasis in liver disease, controversy regarding the need to correct thrombocytopenia and abnormalities in the coagulation system in patients undergoing invasive procedures, and the need for thromboprophylaxis in hospitalised patients with haemostatic abnormalities. Multiple recommendations in this document are based on interventions that the panel feels are not useful, even though widely applied in clinical practice. |
doi_str_mv | 10.1016/j.jhep.2021.09.003 |
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These Clinical Practice Guidelines have been developed to provide practical guidance on debated topics, including current views on haemostasis in liver disease, controversy regarding the need to correct thrombocytopenia and abnormalities in the coagulation system in patients undergoing invasive procedures, and the need for thromboprophylaxis in hospitalised patients with haemostatic abnormalities. Multiple recommendations in this document are based on interventions that the panel feels are not useful, even though widely applied in clinical practice.</description><identifier>ISSN: 0168-8278</identifier><identifier>ISSN: 1600-0641</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2021.09.003</identifier><identifier>PMID: 35300861</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anticoagulants - therapeutic use ; Bleeding ; Cirrhosis ; Clinical practice guidelines ; Hemorrhage - etiology ; Hemorrhage - prevention & control ; Hemostasis ; Humans ; Liver cirrhosis ; Liver Cirrhosis - drug therapy ; Liver diseases ; Patients ; Thrombocytopenia ; Thrombosis ; Thrombosis - etiology ; Thrombosis - prevention & control ; Venous Thromboembolism - drug therapy</subject><ispartof>Journal of hepatology, 2022-05, Vol.76 (5), p.1151-1184</ispartof><rights>2021 European Association for the Study of the Liver</rights><rights>Copyright © 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. May 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-de560584b710a8011cc3de5a62faaaffa3d89121dcd5050318d9f4328842a76c3</citedby><cites>FETCH-LOGICAL-c428t-de560584b710a8011cc3de5a62faaaffa3d89121dcd5050318d9f4328842a76c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016882782102033X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35300861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villa, Erica</creatorcontrib><creatorcontrib>Bianchini, Marcello</creatorcontrib><creatorcontrib>Blasi, Annabel</creatorcontrib><creatorcontrib>Denys, Alban</creatorcontrib><creatorcontrib>Giannini, Edoardo G.</creatorcontrib><creatorcontrib>de Gottardi, Andrea</creatorcontrib><creatorcontrib>Lisman, Ton</creatorcontrib><creatorcontrib>de Raucourt, Emmanuelle</creatorcontrib><creatorcontrib>Ripoll, Cristina</creatorcontrib><creatorcontrib>Rautou, Pierre-Emmanuel</creatorcontrib><creatorcontrib>European Association for the Study of the Liver</creatorcontrib><title>EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>The prevention and management of bleeding and thrombosis in patients with cirrhosis poses several difficult clinical questions. These Clinical Practice Guidelines have been developed to provide practical guidance on debated topics, including current views on haemostasis in liver disease, controversy regarding the need to correct thrombocytopenia and abnormalities in the coagulation system in patients undergoing invasive procedures, and the need for thromboprophylaxis in hospitalised patients with haemostatic abnormalities. Multiple recommendations in this document are based on interventions that the panel feels are not useful, even though widely applied in clinical practice.</description><subject>Anticoagulants - therapeutic use</subject><subject>Bleeding</subject><subject>Cirrhosis</subject><subject>Clinical practice guidelines</subject><subject>Hemorrhage - etiology</subject><subject>Hemorrhage - prevention & control</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - drug therapy</subject><subject>Liver diseases</subject><subject>Patients</subject><subject>Thrombocytopenia</subject><subject>Thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - prevention & control</subject><subject>Venous Thromboembolism - drug therapy</subject><issn>0168-8278</issn><issn>1600-0641</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS1ERbeFP8ABWeLCJenYSby2xKValRZppSIBZ8trT7qOknixnSL-fb1s4cCBk62Z7z2N3iPkLYOaARNXQz3s8VBz4KwGVQM0L8iKCYAKRMteklWBZCX5Wp6Ti5QGKASo9hU5b7oGQAq2Ivnm-uuWbkY_e2tG-iUam71Fert4h2WKiYaZHiI-4px9-ZrZ0cnM5gGnMqGhp7sR0fn54fcq72OYdiH5RH3RmewLlehPn_fU-hj3x9VrctabMeGb5_eSfP90821zV23vbz9vrreVbbnMlcNOQCfb3ZqBkcCYtU2ZGcF7Y0zfm8ZJxThz1nXQQcOkU33bcClbbtbCNpfkw8n3EMOPBVPWk08Wx9HMGJakuWhBqVYJKOj7f9AhLHEu1xVKdR3rBGeF4ifKxpBSxF4fop9M_KUZ6GMnetDHTvSxEw1Kl8SL6N2z9bKb0P2V_CmhAB9PAJYsHj1GnWyJzZZUI9qsXfD_838CP4-dgA</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Villa, Erica</creator><creator>Bianchini, Marcello</creator><creator>Blasi, Annabel</creator><creator>Denys, Alban</creator><creator>Giannini, Edoardo G.</creator><creator>de Gottardi, Andrea</creator><creator>Lisman, Ton</creator><creator>de Raucourt, Emmanuelle</creator><creator>Ripoll, Cristina</creator><creator>Rautou, Pierre-Emmanuel</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>202205</creationdate><title>EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis</title><author>Villa, Erica ; Bianchini, Marcello ; Blasi, Annabel ; Denys, Alban ; Giannini, Edoardo G. ; de Gottardi, Andrea ; Lisman, Ton ; de Raucourt, Emmanuelle ; Ripoll, Cristina ; Rautou, Pierre-Emmanuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-de560584b710a8011cc3de5a62faaaffa3d89121dcd5050318d9f4328842a76c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anticoagulants - therapeutic use</topic><topic>Bleeding</topic><topic>Cirrhosis</topic><topic>Clinical practice guidelines</topic><topic>Hemorrhage - etiology</topic><topic>Hemorrhage - prevention & control</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - drug therapy</topic><topic>Liver diseases</topic><topic>Patients</topic><topic>Thrombocytopenia</topic><topic>Thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - prevention & control</topic><topic>Venous Thromboembolism - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villa, Erica</creatorcontrib><creatorcontrib>Bianchini, Marcello</creatorcontrib><creatorcontrib>Blasi, Annabel</creatorcontrib><creatorcontrib>Denys, Alban</creatorcontrib><creatorcontrib>Giannini, Edoardo G.</creatorcontrib><creatorcontrib>de Gottardi, Andrea</creatorcontrib><creatorcontrib>Lisman, Ton</creatorcontrib><creatorcontrib>de Raucourt, Emmanuelle</creatorcontrib><creatorcontrib>Ripoll, Cristina</creatorcontrib><creatorcontrib>Rautou, Pierre-Emmanuel</creatorcontrib><creatorcontrib>European Association for the Study of the Liver</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villa, Erica</au><au>Bianchini, Marcello</au><au>Blasi, Annabel</au><au>Denys, Alban</au><au>Giannini, Edoardo G.</au><au>de Gottardi, Andrea</au><au>Lisman, Ton</au><au>de Raucourt, Emmanuelle</au><au>Ripoll, Cristina</au><au>Rautou, Pierre-Emmanuel</au><aucorp>European Association for the Study of the Liver</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2022-05</date><risdate>2022</risdate><volume>76</volume><issue>5</issue><spage>1151</spage><epage>1184</epage><pages>1151-1184</pages><issn>0168-8278</issn><issn>1600-0641</issn><eissn>1600-0641</eissn><abstract>The prevention and management of bleeding and thrombosis in patients with cirrhosis poses several difficult clinical questions. These Clinical Practice Guidelines have been developed to provide practical guidance on debated topics, including current views on haemostasis in liver disease, controversy regarding the need to correct thrombocytopenia and abnormalities in the coagulation system in patients undergoing invasive procedures, and the need for thromboprophylaxis in hospitalised patients with haemostatic abnormalities. Multiple recommendations in this document are based on interventions that the panel feels are not useful, even though widely applied in clinical practice.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>35300861</pmid><doi>10.1016/j.jhep.2021.09.003</doi><tpages>34</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Anticoagulants - therapeutic use Bleeding Cirrhosis Clinical practice guidelines Hemorrhage - etiology Hemorrhage - prevention & control Hemostasis Humans Liver cirrhosis Liver Cirrhosis - drug therapy Liver diseases Patients Thrombocytopenia Thrombosis Thrombosis - etiology Thrombosis - prevention & control Venous Thromboembolism - drug therapy |
title | EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis |
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