Systemic hypertonic saline enhances glymphatic spinal cord delivery of lumbar intrathecal morphine

The blood-brain barrier significantly limits effective drug delivery to central nervous system (CNS) targets. The recently characterized glymphatic system offers a perivascular highway for intrathecally (i.t.) administered drugs to reach deep brain structures. Although periarterial cerebrospinal flu...

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Veröffentlicht in:	Journal of controlled release 2022-04, Vol.344, p.214-224
Hauptverfasser:	Blomqvist, Kim J., Skogster, Moritz O.B., Kurkela, Mika J., Rosenholm, Marko P., Ahlström, Fredrik H.G., Airavaara, Mikko T., Backman, Janne T., Rauhala, Pekka V., Kalso, Eija A., Lilius, Tuomas O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Animals Drug delivery Glymphatic system Injections, Spinal Morphine Opioids Osmosis Pain Measurement Rats Rats, Sprague-Dawley Spinal Cord
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