α-Synuclein binding activity of the plant growth promoter asterubine
[Display omitted] Preventing the aggregation of certain amyloid proteins has the potential to slow down the progression of diseases like Alzheimer’s, Parkinson’s, and type 2 diabetes mellitus. During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine s...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2022-05, Vol.64, p.128677-128677, Article 128677 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 64 |
| creator | Prebble, Dale W. Er, Safak Hlushchuk, Irena Domanskyi, Andrii Airavaara, Mikko Ekins, Merrick G. Mellick, George D. Carroll, Anthony R. |
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Preventing the aggregation of certain amyloid proteins has the potential to slow down the progression of diseases like Alzheimer’s, Parkinson’s, and type 2 diabetes mellitus. During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Thorectandra sp. 4408 displayed binding activity to the Parkinson’s disease-associated protein, α-synuclein. Isolation of the active component led to its identification as the known plant growth promoter asterubine (1). This molecule shares distinct structural similarities with potent amyloid beta aggregation inhibitors tramiprosate (homotaurine) and ALZ-801. Herein we report the isolation, NMR data acquired in DMSO and α-synuclein binding activity of asterubine (1). |
| doi_str_mv | 10.1016/j.bmcl.2022.128677 |
| format | Article |
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Preventing the aggregation of certain amyloid proteins has the potential to slow down the progression of diseases like Alzheimer’s, Parkinson’s, and type 2 diabetes mellitus. During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Thorectandra sp. 4408 displayed binding activity to the Parkinson’s disease-associated protein, α-synuclein. Isolation of the active component led to its identification as the known plant growth promoter asterubine (1). This molecule shares distinct structural similarities with potent amyloid beta aggregation inhibitors tramiprosate (homotaurine) and ALZ-801. Herein we report the isolation, NMR data acquired in DMSO and α-synuclein binding activity of asterubine (1).</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2022.128677</identifier><identifier>PMID: 35301136</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alkaloid ; Alpha synuclein ; Amyloid - metabolism ; Amyloid aggregation ; Amyloid beta-Peptides - metabolism ; Australia ; Diabetes Mellitus, Type 2 ; Humans ; Parkinon's disease ; Parkinson Disease - metabolism ; Sponges</subject><ispartof>Bioorganic & medicinal chemistry letters, 2022-05, Vol.64, p.128677-128677, Article 128677</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-7e1b34cc9f38a43e20bf8d7d9e89a451742242a5910c1242641ca41fa4eaa2fd3</citedby><cites>FETCH-LOGICAL-c356t-7e1b34cc9f38a43e20bf8d7d9e89a451742242a5910c1242641ca41fa4eaa2fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2022.128677$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35301136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prebble, Dale W.</creatorcontrib><creatorcontrib>Er, Safak</creatorcontrib><creatorcontrib>Hlushchuk, Irena</creatorcontrib><creatorcontrib>Domanskyi, Andrii</creatorcontrib><creatorcontrib>Airavaara, Mikko</creatorcontrib><creatorcontrib>Ekins, Merrick G.</creatorcontrib><creatorcontrib>Mellick, George D.</creatorcontrib><creatorcontrib>Carroll, Anthony R.</creatorcontrib><title>α-Synuclein binding activity of the plant growth promoter asterubine</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Preventing the aggregation of certain amyloid proteins has the potential to slow down the progression of diseases like Alzheimer’s, Parkinson’s, and type 2 diabetes mellitus. During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Thorectandra sp. 4408 displayed binding activity to the Parkinson’s disease-associated protein, α-synuclein. Isolation of the active component led to its identification as the known plant growth promoter asterubine (1). This molecule shares distinct structural similarities with potent amyloid beta aggregation inhibitors tramiprosate (homotaurine) and ALZ-801. Herein we report the isolation, NMR data acquired in DMSO and α-synuclein binding activity of asterubine (1).</description><subject>Alkaloid</subject><subject>Alpha synuclein</subject><subject>Amyloid - metabolism</subject><subject>Amyloid aggregation</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Australia</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Humans</subject><subject>Parkinon's disease</subject><subject>Parkinson Disease - metabolism</subject><subject>Sponges</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOAzEQRS0EIiHwAxTIJc0ufu1LokFReEiRKACJzvJ6ZxNH-wi2NyifxY_wTThKoKSZmeLeqzsHoUtKYkpoerOKy1Y3MSOMxZTlaZYdoTEVqYi4IMkxGpMiJVFeiPcROnNuRQgVRIhTNOIJJ5TydIxm31_Ry7YbdAOmw6XpKtMtsNLebIzf4r7Gfgl43ajO44XtP_0Sr23f9h4sVi7MIXjgHJ3UqnFwcdgT9HY_e50-RvPnh6fp3TzSPEl9lAEtudC6qHmuBAdGyjqvsqqAvFAioZlgTDCVFJRoGq5UUK0ErZUApVhd8Qm63ueGDh8DOC9b4zQ0oR70g5PBQYoipGRByvZSbXvnLNRybU2r7FZSInf45Eru8MkdPrnHF0xXh_yhbKH6s_zyCoLbvQDClxsDVjptoNNQGQvay6o3_-X_AJ6wgYA</recordid><startdate>20220515</startdate><enddate>20220515</enddate><creator>Prebble, Dale W.</creator><creator>Er, Safak</creator><creator>Hlushchuk, Irena</creator><creator>Domanskyi, Andrii</creator><creator>Airavaara, Mikko</creator><creator>Ekins, Merrick G.</creator><creator>Mellick, George D.</creator><creator>Carroll, Anthony R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220515</creationdate><title>α-Synuclein binding activity of the plant growth promoter asterubine</title><author>Prebble, Dale W. ; Er, Safak ; Hlushchuk, Irena ; Domanskyi, Andrii ; Airavaara, Mikko ; Ekins, Merrick G. ; Mellick, George D. ; Carroll, Anthony R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-7e1b34cc9f38a43e20bf8d7d9e89a451742242a5910c1242641ca41fa4eaa2fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alkaloid</topic><topic>Alpha synuclein</topic><topic>Amyloid - metabolism</topic><topic>Amyloid aggregation</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Australia</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Humans</topic><topic>Parkinon's disease</topic><topic>Parkinson Disease - metabolism</topic><topic>Sponges</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prebble, Dale W.</creatorcontrib><creatorcontrib>Er, Safak</creatorcontrib><creatorcontrib>Hlushchuk, Irena</creatorcontrib><creatorcontrib>Domanskyi, Andrii</creatorcontrib><creatorcontrib>Airavaara, Mikko</creatorcontrib><creatorcontrib>Ekins, Merrick G.</creatorcontrib><creatorcontrib>Mellick, George D.</creatorcontrib><creatorcontrib>Carroll, Anthony R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prebble, Dale W.</au><au>Er, Safak</au><au>Hlushchuk, Irena</au><au>Domanskyi, Andrii</au><au>Airavaara, Mikko</au><au>Ekins, Merrick G.</au><au>Mellick, George D.</au><au>Carroll, Anthony R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>α-Synuclein binding activity of the plant growth promoter asterubine</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2022-05-15</date><risdate>2022</risdate><volume>64</volume><spage>128677</spage><epage>128677</epage><pages>128677-128677</pages><artnum>128677</artnum><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
Preventing the aggregation of certain amyloid proteins has the potential to slow down the progression of diseases like Alzheimer’s, Parkinson’s, and type 2 diabetes mellitus. During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Thorectandra sp. 4408 displayed binding activity to the Parkinson’s disease-associated protein, α-synuclein. Isolation of the active component led to its identification as the known plant growth promoter asterubine (1). This molecule shares distinct structural similarities with potent amyloid beta aggregation inhibitors tramiprosate (homotaurine) and ALZ-801. Herein we report the isolation, NMR data acquired in DMSO and α-synuclein binding activity of asterubine (1).</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35301136</pmid><doi>10.1016/j.bmcl.2022.128677</doi><tpages>1</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2022-05, Vol.64, p.128677-128677, Article 128677 |
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| subjects | Alkaloid Alpha synuclein Amyloid - metabolism Amyloid aggregation Amyloid beta-Peptides - metabolism Australia Diabetes Mellitus, Type 2 Humans Parkinon's disease Parkinson Disease - metabolism Sponges |
| title | α-Synuclein binding activity of the plant growth promoter asterubine |
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