Importin KPNA2 confers HIV-1 pre-integration complex nuclear import by interacting with the capsid protein

For human immunodeficiency virus 1 (HIV-1) to infect non-dividing cells, pre-integration complex (PIC) must be transported into the nucleus within the replication cycle. We previously reported that the karyopherin β1 (KPNB1)–nucleoporin Pom121 pathway, related to the downstream process of PIC nuclea...

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Veröffentlicht in:	Antiviral research 2022-04, Vol.200, p.105289-105289, Article 105289
Hauptverfasser:	Song, Yanhui, Zhang, Hongguang, Wang, Yinmiao, Guo, Jin, Tang, Shengjie, Wang, Lu, Peng, Ke, Dong, Chun-sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus alpha Karyopherins - genetics alpha Karyopherins - metabolism Capsid Proteins - genetics Capsid Proteins - metabolism Cell Nucleus - metabolism HIV-1 HIV-1 - genetics HIV-1 - metabolism Humans Karyopherins - metabolism KPNA2 Membrane Glycoproteins - metabolism Nuclear import Viral replication Virus Replication
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