A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer

An epithelial-to-mesenchymal transition (EMT) phenotype with cancer stem cell-like properties is a critical feature of aggressive/metastatic tumors, but the mechanism(s) that promote it and its relation to metabolic stress remain unknown. Here we show that Collapsin Response Mediator Protein 2A (CRM...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-03, Vol.38 (11), p.110511-110511, Article 110511
Hauptverfasser:	Boukouris, Aristeidis E., Zhang, Yongneng, Saleme, Bruno, Kinnaird, Adam, Zhao, Yuan Yuan, Liu, Yongsheng, Zervopoulos, Sotirios D., Das, Subhash K., Mittal, Rohan D., Haromy, Alois, Lorenzana-Carrillo, Maria Areli, Krysler, Amanda R., Cromwell, Christopher R., Hubbard, Basil P., Sutendra, Gopinath, Michelakis, Evangelos D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor cytoskeleton Epithelial-Mesenchymal Transition - genetics Humans Intercellular Signaling Peptides and Proteins - metabolism Male metabolism metastasis microtubule mitochondria Neoplastic Stem Cells - metabolism Nerve Tissue Proteins - metabolism Prostatic Neoplasms - pathology Semaphorin-3A - metabolism stress Stress, Physiological
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