Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling

G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular functions. Cells express many different GPCRs, but all these GPCRs signal to only a few second messengers such as cAMP. It is largely unknown how cells distinguish between signals triggered by different GPCRs to o...

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Veröffentlicht in:	Cell 2022-03, Vol.185 (7), p.1130-1142.e11
Hauptverfasser:	Anton, Selma E., Kayser, Charlotte, Maiellaro, Isabella, Nemec, Katarina, Möller, Jan, Koschinski, Andreas, Zaccolo, Manuela, Annibale, Paolo, Falcke, Martin, Lohse, Martin J., Bock, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	biosensors cAMP Cell Physiological Phenomena cell signaling compartmentation Cyclic AMP diffusion FRET G protein-coupled receptors GLP-1 Glucagon-Like Peptide 1 nanodomains Receptors, Adrenergic, beta-2 Receptors, G-Protein-Coupled - chemistry Second Messenger Systems Signal Transduction spatiotemporal signaling
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