Selective Antitumor Activity and Photocytotoxicity of Glutathione-Activated Abasic Site Trapping Agents

Abasic (AP) sites are one of the most common DNA lesions in cells. Aldehyde-reactive alkoxyamines capture AP sites and block the activity of APE1, the enzyme responsible for initiating their repair. Blocking the APE1 repair of AP sites leads to cell death, and it is an actively investigated approach...

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Veröffentlicht in:	ACS chemical biology 2022-04, Vol.17 (4), p.797-803
Hauptverfasser:	Xue, Li, Yu, Dehao, Wang, Lingling, Sun, Jing, Song, Ying, Jia, Yuanyuan, Wu, Ang, Zhang, Beibei, Mi, Wenyi, Fan, Heli, Sun, Huabing
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Line, Tumor DNA - metabolism DNA Damage DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Glutathione Humans
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