Cananginone Abrogates EMT in Breast Cancer Cells through Hedgehog Signaling

Cananginones, a family of linear acetogenins found as secondary metabolites in the plant kingdom, show cytotoxicity against several types of cancer cells. We aimed to investigate the efficacy of cananginone and its mechanism as an anti‐cancer agent. Our initial screening of Cananginone against HepG2...

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Veröffentlicht in:	Chemistry & biodiversity 2022-05, Vol.19 (5), p.e202100823-n/a
Hauptverfasser:	Bose, Chandra, Das, Ujjal, Kuilya, Tapan Kumar, Mondal, Joyanta, Bhadra, Jhuma, Banerjee, Priyanjalee, Goswami, Rajib Kumar, Sinha, Surajit
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagonists Breast cancer Breast Neoplasms - drug therapy cananginone Cancer Cell Line, Tumor Cytotoxicity epithelial to mesenchymal transition (EMT) Epithelial-Mesenchymal Transition Female hedgehog Hedgehog protein Hedgehog Proteins - metabolism Humans Mesenchyme Metabolites natural product Secondary metabolites Stem cells Toxicity Zinc Finger Protein GLI1 - metabolism
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