Nicotine Activating α4β2 Nicotinic Acetylcholine Receptors to Suppress Neuroinflammation via JAK2-STAT3 Signaling Pathway in Ischemic Rats and Inflammatory Cells

Nicotine plays a role in inhibiting inflammatory factors, which contributes to improving cognitive impairment by activating α 4 β 2 nAChRs in ischemic rats, but the underlying mechanism has not been fully elucidated. Janus tyrosine kinase 2-signal transducer and activator of transcription 3 (JAK2-ST...

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Veröffentlicht in:	Molecular neurobiology 2022-05, Vol.59 (5), p.3280-3293
Hauptverfasser:	Wang, Qi, Gou, Jinyu, Guo, Shenrui, Wei, Feng, Han, Tingting, Lai, Ruihe, Zhang, Dalong, Diao, Yao, Yin, Yafu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Biomedical and Life Sciences Biomedicine Cell Biology Cognitive ability Inflammation Ischemia Janus kinase 2 Kinases Lipopolysaccharides Neurobiology Neurology Neurosciences Nicotine Positron emission tomography Protein-tyrosine kinase Signal transduction Stat3 protein Transcription
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