Honokiol ameliorates cisplatin‐induced acute kidney injury via inhibition of mitochondrial fission

Background and Purpose Mitochondrial damage and oxidative stress are crucial contributors to the tubular cell injury and death in acute kidney injury. Novel therapeutic strategies targeting mitochondria protection and halting the progression of acute kidney injury are urgently needed. Honokiol is a...

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Veröffentlicht in:	British journal of pharmacology 2022-07, Vol.179 (14), p.3886-3904
Hauptverfasser:	Mao, Rui‐wen, He, Shan‐ping, Lan, Jun‐gang, Zhu, Wu‐zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Apoptosis Cell death Cell injury Chemotherapy Cisplatin Flow cytometry honokiol Immunoblotting Immunofluorescence Immunohistochemistry Immunoprecipitation Inflammation Kidneys Mitochondria mitochondrial fission mtROS Oxidative stress Phosphorylation Reactive oxygen species SIRT3 Transfection Transmission electron microscopy
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