Protective effects of tadalafil against cisplatin-induced spermatogenic dysfunction

Cisplatin (CDDP) is an effective anticancer drug for the treatment of malignant tumors, such as lung cancer, bladder cancer, and testicular cancer. However, oligozoospermia and azoospermia after administration of CDDP are clinical problems. One of the testicular toxicities of CDDP is known to cause...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-05, Vol.603, p.123-129
Hauptverfasser:	Kaku, Yasuhiro, Chiba, Koji, Sato, Katsuya, Onishi, Atsushi, Ishida, Takaki, Okada, Keisuke, Fujisawa, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Atrophy Cisplatin Cisplatin - adverse effects Dimethyl Sulfoxide - pharmacology Humans Male Oxidative Stress Protective effect Rats Spermatogenic dysfunction Tadalafil Tadalafil - pharmacology Tadalafil - therapeutic use Testicular Neoplasms Testis
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