Association of the rs4143815 polymorphism of PDL1 gene with HTLV‐1 infection and proviral load in asymptomatic blood donors in northeast Iran
It is obvious that genetic differences, including mutations and polymorphisms, can play an important role in viral infections. In this case–control study, which included 81 human T‐cell leukemia virus type 1 (HTLV‐1) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphis...
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| Veröffentlicht in: | Microbiology and immunology 2022-06, Vol.66 (6), p.324-329 |
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| creator | Hezave, Yalda Amiri Sharifi, Zohreh Kermani, Fahime Ranjbar Shahabi, Majide |
| description | It is obvious that genetic differences, including mutations and polymorphisms, can play an important role in viral infections. In this case–control study, which included 81 human T‐cell leukemia virus type 1 (HTLV‐1) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphism of PDL1 gene was investigated. This polymorphism is the site of miR‐570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele‐specific polymerase chain reaction (AS‐PCR) and the proviral load levels by quantitative real‐time PCR (q PCR). The results demonstrated that the C allele (P = 0.027) and the CC genotype (P = 0.031) of rs4143815 polymorphism was significantly higher in the AC group than in the HC group, also the proviral load in the AC group with the C allele (P = 0.020) was significantly higher. Thus, the rs4143815 polymorphism can play a vital role in HTLV‐1 infection |
| doi_str_mv | 10.1111/1348-0421.12976 |
| format | Article |
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In this case–control study, which included 81 human T‐cell leukemia virus type 1 (HTLV‐1) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphism of PDL1 gene was investigated. This polymorphism is the site of miR‐570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele‐specific polymerase chain reaction (AS‐PCR) and the proviral load levels by quantitative real‐time PCR (q PCR). The results demonstrated that the C allele (P = 0.027) and the CC genotype (P = 0.031) of rs4143815 polymorphism was significantly higher in the AC group than in the HC group, also the proviral load in the AC group with the C allele (P = 0.020) was significantly higher. 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In this case–control study, which included 81 human T‐cell leukemia virus type 1 (HTLV‐1) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphism of PDL1 gene was investigated. This polymorphism is the site of miR‐570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele‐specific polymerase chain reaction (AS‐PCR) and the proviral load levels by quantitative real‐time PCR (q PCR). The results demonstrated that the C allele (P = 0.027) and the CC genotype (P = 0.031) of rs4143815 polymorphism was significantly higher in the AC group than in the HC group, also the proviral load in the AC group with the C allele (P = 0.020) was significantly higher. 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In this case–control study, which included 81 human T‐cell leukemia virus type 1 (HTLV‐1) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphism of PDL1 gene was investigated. This polymorphism is the site of miR‐570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele‐specific polymerase chain reaction (AS‐PCR) and the proviral load levels by quantitative real‐time PCR (q PCR). The results demonstrated that the C allele (P = 0.027) and the CC genotype (P = 0.031) of rs4143815 polymorphism was significantly higher in the AC group than in the HC group, also the proviral load in the AC group with the C allele (P = 0.020) was significantly higher. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; Freely Accessible Japanese Titles; Alma/SFX Local Collection |
| subjects | Alleles Blood Donors Case-Control Studies Gene polymorphism HTLV-I Infections - genetics Human T-lymphotropic virus 1 - genetics human T‐lymphotropic virus 1 Humans Immune system Iran PD‐L1 Polymerase chain reaction Proviruses - genetics Real-Time Polymerase Chain Reaction Viral Load |
| title | Association of the rs4143815 polymorphism of PDL1 gene with HTLV‐1 infection and proviral load in asymptomatic blood donors in northeast Iran |
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