If it ain’t broke, break it: facilitating antigen cross-presentation
Recently, Bikorimana et al. presented a new vaccine formulation, AccumTM, capable of eliciting efficient T cell-mediated immune responses and controlling tumour growth. AccumTM is designed to facilitate cross-presentation by breaking through endo/lysosomal membranes and enhancing delivery of antigen...
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| Veröffentlicht in: | Trends in molecular medicine 2022-04, Vol.28 (4), p.251-252 |
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| container_title | Trends in molecular medicine |
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| creator | Rodríguez-Silvestre, Pablo Kozik, Patrycja |
| description | Recently, Bikorimana et al. presented a new vaccine formulation, AccumTM, capable of eliciting efficient T cell-mediated immune responses and controlling tumour growth. AccumTM is designed to facilitate cross-presentation by breaking through endo/lysosomal membranes and enhancing delivery of antigens into the cytosol of dendritic cells (DCs). |
| doi_str_mv | 10.1016/j.molmed.2022.02.007 |
| format | Article |
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| ispartof | Trends in molecular medicine, 2022-04, Vol.28 (4), p.251-252 |
| issn | 1471-4914 1471-499X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antigen Presentation Antigens cancer vaccines cross-presentation Cross-Priming Dendritic Cells endosomal escape Humans immunotherapy Lysosomes |
| title | If it ain’t broke, break it: facilitating antigen cross-presentation |
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