Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking
pH-responsive capsule particles show promise for various applications, such as self-healing materials, micro/nanoreactors, and drug delivery systems. Herein, carboxy-functionalized capsule polymer particles possessing neutral-alkaline pH responsive controlled release capability were newly fabricated...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2022-09, Vol.1 (37), p.757-758 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Kitayama, Yukiya Harada, Atsushi |
| description | pH-responsive capsule particles show promise for various applications, such as self-healing materials, micro/nanoreactors, and drug delivery systems. Herein, carboxy-functionalized capsule polymer particles possessing neutral-alkaline pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer [poly(2-carboxyethyl acrylate-
co
-2-cinnamoylethyl methacrylate): P(CEA-CEMA)] particles and a subsequent encapsulation process. Using P(CEA-CEMA) particles, the shell-crosslinked hollow polymer particles were fabricated by the particulate interfacial photocrosslinking procedure. Furthermore, the encapsulation of sulforhodamine B as a model dye into the hollow particles was also performed. Under acidic pH conditions, encapsulated molecules were stably retained in the P(CEA-CEMA) capsules with negligible release of sulforhodamine B. However, the encapsulated sulforhodamine B was gradually or drastically released from the capsule particles under neutral or basic conditions, respectively, indicating that the neutral-alkaline pH responsive controlled release from the capsules was successfully achieved by regulating the release kinetics. These results demonstrate that the fabrication routes of hollow and capsule particles based on particulate interfacial photocrosslinking can be successfully applied to carboxy-functionalized photoreactive polymer particles, and the capsule polymer particles possessing pH-responsive release properties under neutral-basic conditions were successfully fabricated.
Carboxy-functionalized capsule polymer particles possessing neutral-alkali pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer particles. |
| doi_str_mv | 10.1039/d1tb02866a |
| format | Article |
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co
-2-cinnamoylethyl methacrylate): P(CEA-CEMA)] particles and a subsequent encapsulation process. Using P(CEA-CEMA) particles, the shell-crosslinked hollow polymer particles were fabricated by the particulate interfacial photocrosslinking procedure. Furthermore, the encapsulation of sulforhodamine B as a model dye into the hollow particles was also performed. Under acidic pH conditions, encapsulated molecules were stably retained in the P(CEA-CEMA) capsules with negligible release of sulforhodamine B. However, the encapsulated sulforhodamine B was gradually or drastically released from the capsule particles under neutral or basic conditions, respectively, indicating that the neutral-alkaline pH responsive controlled release from the capsules was successfully achieved by regulating the release kinetics. These results demonstrate that the fabrication routes of hollow and capsule particles based on particulate interfacial photocrosslinking can be successfully applied to carboxy-functionalized photoreactive polymer particles, and the capsule polymer particles possessing pH-responsive release properties under neutral-basic conditions were successfully fabricated.
Carboxy-functionalized capsule polymer particles possessing neutral-alkali pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer particles.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d1tb02866a</identifier><identifier>PMID: 35279710</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Controlled release ; Drug delivery ; Drug delivery systems ; Encapsulation ; Fabrication ; pH effects ; Polymers ; Self healing materials ; Sulforhodamine</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2022-09, Vol.1 (37), p.757-758</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-23b465a1bfd449e2b4229442c9356c6126e5aab5a2103666c86b4680b8e53b3e3</citedby><cites>FETCH-LOGICAL-c333t-23b465a1bfd449e2b4229442c9356c6126e5aab5a2103666c86b4680b8e53b3e3</cites><orcidid>0000-0002-9485-2110 ; 0000-0002-7418-301X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35279710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitayama, Yukiya</creatorcontrib><creatorcontrib>Harada, Atsushi</creatorcontrib><title>Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>pH-responsive capsule particles show promise for various applications, such as self-healing materials, micro/nanoreactors, and drug delivery systems. Herein, carboxy-functionalized capsule polymer particles possessing neutral-alkaline pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer [poly(2-carboxyethyl acrylate-
co
-2-cinnamoylethyl methacrylate): P(CEA-CEMA)] particles and a subsequent encapsulation process. Using P(CEA-CEMA) particles, the shell-crosslinked hollow polymer particles were fabricated by the particulate interfacial photocrosslinking procedure. Furthermore, the encapsulation of sulforhodamine B as a model dye into the hollow particles was also performed. Under acidic pH conditions, encapsulated molecules were stably retained in the P(CEA-CEMA) capsules with negligible release of sulforhodamine B. However, the encapsulated sulforhodamine B was gradually or drastically released from the capsule particles under neutral or basic conditions, respectively, indicating that the neutral-alkaline pH responsive controlled release from the capsules was successfully achieved by regulating the release kinetics. These results demonstrate that the fabrication routes of hollow and capsule particles based on particulate interfacial photocrosslinking can be successfully applied to carboxy-functionalized photoreactive polymer particles, and the capsule polymer particles possessing pH-responsive release properties under neutral-basic conditions were successfully fabricated.
Carboxy-functionalized capsule polymer particles possessing neutral-alkali pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer particles.</description><subject>Controlled release</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Encapsulation</subject><subject>Fabrication</subject><subject>pH effects</subject><subject>Polymers</subject><subject>Self healing materials</subject><subject>Sulforhodamine</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkc1LxDAQxYMoKroX70rBiwjVfDRpetT1EwQvCt5Kkp1qNNvUpBXXv96su67gXDKT_N5A3kNoj-ATgll1OiG9xlQKodbQNsUc5yUncn3V46ctNIrxFaeSREhWbKItxmlZlQRvo4-xCtp_zvJmaE1vfauc_YJJ1t1kAWLn22g_IDOqi4ODrPNuNoWQdSr01jiIWaN0sEb1SaJny_vBpTmzbQ-hUcYql3Uvvvcm-Bidbd9s-7yLNhrlIoyW5w56vLp8GN_kd_fXt-Ozu9wwxvqcMl0IrohuJkVRAdUFpVVRUFMxLowgVABXSnNFkxdCCCNFEkisJXCmGbAddLTY2wX_PkDs66mNBpxTLfgh1lQwWQmChUjo4T_01Q8h-ZGokkhBZcnn1PGC-vlNgKbugp2qMKsJrueB1Bfk4fwnkLMEHyxXDnoKkxX6a38C9hdAiGb1-pco-wbdspFV</recordid><startdate>20220928</startdate><enddate>20220928</enddate><creator>Kitayama, Yukiya</creator><creator>Harada, Atsushi</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9485-2110</orcidid><orcidid>https://orcid.org/0000-0002-7418-301X</orcidid></search><sort><creationdate>20220928</creationdate><title>Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking</title><author>Kitayama, Yukiya ; Harada, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-23b465a1bfd449e2b4229442c9356c6126e5aab5a2103666c86b4680b8e53b3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Controlled release</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Encapsulation</topic><topic>Fabrication</topic><topic>pH effects</topic><topic>Polymers</topic><topic>Self healing materials</topic><topic>Sulforhodamine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitayama, Yukiya</creatorcontrib><creatorcontrib>Harada, Atsushi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitayama, Yukiya</au><au>Harada, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2022-09-28</date><risdate>2022</risdate><volume>1</volume><issue>37</issue><spage>757</spage><epage>758</epage><pages>757-758</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>pH-responsive capsule particles show promise for various applications, such as self-healing materials, micro/nanoreactors, and drug delivery systems. Herein, carboxy-functionalized capsule polymer particles possessing neutral-alkaline pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer [poly(2-carboxyethyl acrylate-
co
-2-cinnamoylethyl methacrylate): P(CEA-CEMA)] particles and a subsequent encapsulation process. Using P(CEA-CEMA) particles, the shell-crosslinked hollow polymer particles were fabricated by the particulate interfacial photocrosslinking procedure. Furthermore, the encapsulation of sulforhodamine B as a model dye into the hollow particles was also performed. Under acidic pH conditions, encapsulated molecules were stably retained in the P(CEA-CEMA) capsules with negligible release of sulforhodamine B. However, the encapsulated sulforhodamine B was gradually or drastically released from the capsule particles under neutral or basic conditions, respectively, indicating that the neutral-alkaline pH responsive controlled release from the capsules was successfully achieved by regulating the release kinetics. These results demonstrate that the fabrication routes of hollow and capsule particles based on particulate interfacial photocrosslinking can be successfully applied to carboxy-functionalized photoreactive polymer particles, and the capsule polymer particles possessing pH-responsive release properties under neutral-basic conditions were successfully fabricated.
Carboxy-functionalized capsule polymer particles possessing neutral-alkali pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer particles.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35279710</pmid><doi>10.1039/d1tb02866a</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9485-2110</orcidid><orcidid>https://orcid.org/0000-0002-7418-301X</orcidid></addata></record> |
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| issn | 2050-750X 2050-7518 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Controlled release Drug delivery Drug delivery systems Encapsulation Fabrication pH effects Polymers Self healing materials Sulforhodamine |
| title | Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking |
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