Protective effects of heterophyllin B against bleomycin-induced pulmonary fibrosis in mice via AMPK activation

Pulmonary fibrosis (PF) is a chronic interstitial lung disease with unknown etiology. In the present study, we evaluated the anti-fibrotic effects of heterophyllin B, a natural product from Radix Pseudostellariae having anti-inflammatory and tyrosinase inhibitory activities. In bleomycin (BLM)-induc...

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Veröffentlicht in:	European journal of pharmacology 2022-04, Vol.921, p.174825-174825, Article 174825
Hauptverfasser:	Shi, Wen, Hao, Jiatong, Wu, Yanliang, Liu, Chang, Shimizu, Kuniyoshi, Li, Renshi, Zhang, Chaofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism AMPK activation Animals Bleomycin - toxicity Epithelial-Mesenchymal Transition Heterophyllin B Lung Mice Peptides, Cyclic - pharmacology Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - prevention & control STING
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