Role of IGF-1 in neuroinflammation and cognition deficits induced by sleep deprivation

•Sleep deprivation results in IGF-1 down-regulation in the hippocampus.•IGF-1 can attenuates the cognitive decline after sleep deprivation.•IGF-1 modulates the inflammatory response and apoptosis by regulating the PI3/AKT/GSK-3β pathway after sleep deprivation. Sleep deprivation negatively influence...

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Veröffentlicht in:	Neuroscience letters 2022-04, Vol.776, p.136575-136575, Article 136575
Hauptverfasser:	Wan, Yahui, Gao, Wei, Zhou, Kaili, Liu, Xuan, Jiang, Wei, Xue, Rong, Wu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cognition Cognitive Dysfunction - etiology Cognitive impairment Glycogen Synthase Kinase 3 beta IGF-1 Inflammation Insulin-Like Growth Factor I - pharmacology Mice Neuroinflammatory Diseases Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Sleep deprivation Sleep Deprivation - complications
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