Kidney and plasma metabolomics provide insights into the molecular mechanisms of urate nephropathy in a mouse model of hyperuricemia

Hyperuricemia (HUA) is closely associated with kidney damage and kidney diseases in humans; however, the underlying mechanisms of HUA-induced kidney diseases remain unknown. In the present study, we examined the kidney and plasma metabolic profiles in a HUA mouse model constructed by knocking out (K...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-06, Vol.1868 (6), p.166374-166374, Article 166374
Hauptverfasser:	Li, Hailong, Zhang, Hui, Yan, Fei, He, Yuwei, Ji, Aichang, Liu, Zhen, Li, Maichao, Ji, Xiaopeng, Li, Changgui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hyperuricemia Hyperuricemia - drug therapy Hyperuricemia - genetics Kidney - pathology Kidney Diseases - genetics Kidney Diseases - pathology Metabolite biomarkers Metabolomics Mice Urate nephropathy Uric Acid - metabolism Uricase oxidase
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