Box-Behnken design optimized silibinin loaded glycerylmonooleate nanoliquid crystal for brain targeting

Silibinin (SIL) is a neuroprotective and amyloid aggregate inhibitor that showed therapeutic applications in preclinical studies of Alzheimer’s disease (AD). Due to poor aqueous solubility free SIL is unable to reach the brain after oral administration. Therefore SIL was encapsulated in nano-liquid...

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Veröffentlicht in:	Chemistry and physics of lipids 2022-05, Vol.244, p.105193-105193, Article 105193
Hauptverfasser:	Singh, Ajit, Vaish, Ajay, Shukla, Rahul
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Box-Behnken design Brain uptake Nanoliquid crystals Silibinin
Online-Zugang:	Volltext
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