Elevated expression of urokinase plasminogen activator in rodent models and patients with cerebral amyloid angiopathy

Aims The aim of this work is to study the association of urokinase plasminogen activator (uPA) with development and progression of cerebral amyloid angiopathy (CAA). Materials and methods We studied the expression of uPA mRNA by quantitative polymerase chain reaction (qPCR) and co‐localisation of uP...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2022-08, Vol.48 (5), p.e12804-n/a
Hauptverfasser:	Vervuurt, Marc, Zhu, Xiaoyue, Schrader, Joseph, Kort, Anna M., Marques, Tainá M., Kersten, Iris, Peters van Ton, Annemieke M., Abdo, Wilson F., Schreuder, Floris H. B. M., Rasing, Ingeborg, Terwindt, Gisela M., Wermer, Marieke J. H., Greenberg, Steven M., Klijn, Catharina J. M., Kuiperij, H. Bea, Van Nostrand, William E., Verbeek, Marcel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age amyloid beta Animal models biomarker Cerebral amyloid angiopathy Cerebrospinal fluid Enzyme-linked immunosorbent assay Gene expression Immunohistochemistry Microvasculature Patients U-Plasminogen activator urokinase plasminogen activator β-Amyloid
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