Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction
The aim of this study is to evaluate the value of the haematologic inflammatory parameters in predicting sperm retrieval rates during microdissection testicular sperm extraction (micro‐TESE).159 patients diagnosed with non‐obstructive azoospermia were included in the study. After excluding the patie...
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| Veröffentlicht in: | Andrologia 2022-07, Vol.54 (6), p.e14419-n/a |
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| creator | Bastug, Yavuz Tokuc, Emre Bastug, Nesrin Artuk, Ilker Tosun, Cagatay Cakiroglu, Halime Sena Aykan, Serdar |
| description | The aim of this study is to evaluate the value of the haematologic inflammatory parameters in predicting sperm retrieval rates during microdissection testicular sperm extraction (micro‐TESE).159 patients diagnosed with non‐obstructive azoospermia were included in the study. After excluding the patients that do not fit the inclusion criteria, age, smoking status, body‐mass index, serum luteinizing hormone, follicle‐stimulating hormone, total testosterone levels and neutrophil, lymphocyte and platelet counts were recorded. Neutrophil‐lymphocyte ratio, platelet‐lymphocyte ratio and systemic immune‐inflammation index were calculated. The primary outcome was defined as the presence of spermatozoa during the procedure and the association between the candidate predictors and primary endpoint were evaluated by logistic regression analysis. Then, a baseline model from age, smoking, body‐mass index and hormonal levels was built. Ratios and indexes were included, respectively, and were compared by multivariate analyses. Each of all three parameters was an independent predictor of obtaining spermatozoa during micro‐TESE procedure (all p |
| doi_str_mv | 10.1111/and.14419 |
| format | Article |
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After excluding the patients that do not fit the inclusion criteria, age, smoking status, body‐mass index, serum luteinizing hormone, follicle‐stimulating hormone, total testosterone levels and neutrophil, lymphocyte and platelet counts were recorded. Neutrophil‐lymphocyte ratio, platelet‐lymphocyte ratio and systemic immune‐inflammation index were calculated. The primary outcome was defined as the presence of spermatozoa during the procedure and the association between the candidate predictors and primary endpoint were evaluated by logistic regression analysis. Then, a baseline model from age, smoking, body‐mass index and hormonal levels was built. Ratios and indexes were included, respectively, and were compared by multivariate analyses. Each of all three parameters was an independent predictor of obtaining spermatozoa during micro‐TESE procedure (all p < 0.001). Even though all three parameters were significant, neutrophil‐lymphocyte ratio and systemic immune‐inflammation index stood out as more powerful than platelet‐lymphocyte ratio (p < 0.08, p < 0.08 respectively). Additionally, adding these parameters individually to the baseline model significantly empowered the predictive value (all p < 0.001). Using haematologic inflammatory parameters in the prediction of sperm presence during microdissection testicular sperm extraction may be helpful when consulting the patient with having a better foresight of the procedural outcomes.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.14419</identifier><identifier>PMID: 35266170</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Azoospermia ; Humans ; Inflammation ; inflammatory markers ; Leukocytes (neutrophilic) ; Luteinizing hormone ; Lymphocytes ; Male ; Microdissection - methods ; microdissection testicular sperm extraction ; Neutrophils ; Platelets ; prediction model ; Retrospective Studies ; Smoking ; Sperm ; Sperm Retrieval ; Spermatozoa ; Testes ; Testis - surgery ; Testosterone</subject><ispartof>Andrologia, 2022-07, Vol.54 (6), p.e14419-n/a</ispartof><rights>2022 Wiley‐VCH GmbH</rights><rights>2022 Wiley-VCH GmbH.</rights><rights>Copyright © 2022 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-4f78674c380a5040ca1bc419a4b56dfd506f70d08d93233defe20136f0136ce3</citedby><cites>FETCH-LOGICAL-c3539-4f78674c380a5040ca1bc419a4b56dfd506f70d08d93233defe20136f0136ce3</cites><orcidid>0000-0001-8221-8158 ; 0000-0002-7889-4943 ; 0000-0002-5885-9278 ; 0000-0001-8963-6811 ; 0000-0002-9256-940X ; 0000-0002-2341-2230 ; 0000-0003-4879-7947</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.14419$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.14419$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35266170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bastug, Yavuz</creatorcontrib><creatorcontrib>Tokuc, Emre</creatorcontrib><creatorcontrib>Bastug, Nesrin</creatorcontrib><creatorcontrib>Artuk, Ilker</creatorcontrib><creatorcontrib>Tosun, Cagatay</creatorcontrib><creatorcontrib>Cakiroglu, Halime Sena</creatorcontrib><creatorcontrib>Aykan, Serdar</creatorcontrib><title>Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>The aim of this study is to evaluate the value of the haematologic inflammatory parameters in predicting sperm retrieval rates during microdissection testicular sperm extraction (micro‐TESE).159 patients diagnosed with non‐obstructive azoospermia were included in the study. After excluding the patients that do not fit the inclusion criteria, age, smoking status, body‐mass index, serum luteinizing hormone, follicle‐stimulating hormone, total testosterone levels and neutrophil, lymphocyte and platelet counts were recorded. Neutrophil‐lymphocyte ratio, platelet‐lymphocyte ratio and systemic immune‐inflammation index were calculated. The primary outcome was defined as the presence of spermatozoa during the procedure and the association between the candidate predictors and primary endpoint were evaluated by logistic regression analysis. Then, a baseline model from age, smoking, body‐mass index and hormonal levels was built. Ratios and indexes were included, respectively, and were compared by multivariate analyses. Each of all three parameters was an independent predictor of obtaining spermatozoa during micro‐TESE procedure (all p < 0.001). Even though all three parameters were significant, neutrophil‐lymphocyte ratio and systemic immune‐inflammation index stood out as more powerful than platelet‐lymphocyte ratio (p < 0.08, p < 0.08 respectively). Additionally, adding these parameters individually to the baseline model significantly empowered the predictive value (all p < 0.001). Using haematologic inflammatory parameters in the prediction of sperm presence during microdissection testicular sperm extraction may be helpful when consulting the patient with having a better foresight of the procedural outcomes.</description><subject>Azoospermia</subject><subject>Humans</subject><subject>Inflammation</subject><subject>inflammatory markers</subject><subject>Leukocytes (neutrophilic)</subject><subject>Luteinizing hormone</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Microdissection - methods</subject><subject>microdissection testicular sperm extraction</subject><subject>Neutrophils</subject><subject>Platelets</subject><subject>prediction model</subject><subject>Retrospective Studies</subject><subject>Smoking</subject><subject>Sperm</subject><subject>Sperm Retrieval</subject><subject>Spermatozoa</subject><subject>Testes</subject><subject>Testis - surgery</subject><subject>Testosterone</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1uFDEQhS1EREZJFlwAWWIDEpPYbbd7ZhmFXylKFmTf8thlxZHtbmy3SO84AnfhRpyEmh9YIKiFLbk-vXp-Rchzzs451oVO9pxLyddPyIJLsV6ypmuekgUTTCxlq9bH5KyUB4Yl266T8hk5Fm2jFO_Ygvz4PJcK0RvqY5wS_Pz23ScXdIy6-iFRnyw8vqEJppqH8d4HBMIcx_vBzBVo3lIULdAx6AoB6j_7GeiYwXpTh1zo4GgZIcftW4FkAKdQtJAH60sBsxtcoVRvpqDzAYbHmvWud0qOnA4Fzg73Cbl7_-7u6uPy-vbDp6vL66URLeYgXbdSnTRixXTLJDOabwzmpOWmVdbZlinXMctWdi0aISw4aBgXym0PA-KEvNrLjnn4MqGdPvpiIASdYJhK3yhU5pI1DNGXf6EPw5QTmkOqU7xplZJIvd5T-NNSMrh-zD7qPPec9dtd9hhkv9slsi8OitMmgv1D_t4cAhd74KsPMP9fqb-8ebuX_AXzkLAG</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Bastug, Yavuz</creator><creator>Tokuc, Emre</creator><creator>Bastug, Nesrin</creator><creator>Artuk, Ilker</creator><creator>Tosun, Cagatay</creator><creator>Cakiroglu, Halime Sena</creator><creator>Aykan, Serdar</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8221-8158</orcidid><orcidid>https://orcid.org/0000-0002-7889-4943</orcidid><orcidid>https://orcid.org/0000-0002-5885-9278</orcidid><orcidid>https://orcid.org/0000-0001-8963-6811</orcidid><orcidid>https://orcid.org/0000-0002-9256-940X</orcidid><orcidid>https://orcid.org/0000-0002-2341-2230</orcidid><orcidid>https://orcid.org/0000-0003-4879-7947</orcidid></search><sort><creationdate>202207</creationdate><title>Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction</title><author>Bastug, Yavuz ; Tokuc, Emre ; Bastug, Nesrin ; Artuk, Ilker ; Tosun, Cagatay ; Cakiroglu, Halime Sena ; Aykan, Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-4f78674c380a5040ca1bc419a4b56dfd506f70d08d93233defe20136f0136ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Azoospermia</topic><topic>Humans</topic><topic>Inflammation</topic><topic>inflammatory markers</topic><topic>Leukocytes (neutrophilic)</topic><topic>Luteinizing hormone</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Microdissection - methods</topic><topic>microdissection testicular sperm extraction</topic><topic>Neutrophils</topic><topic>Platelets</topic><topic>prediction model</topic><topic>Retrospective Studies</topic><topic>Smoking</topic><topic>Sperm</topic><topic>Sperm Retrieval</topic><topic>Spermatozoa</topic><topic>Testes</topic><topic>Testis - surgery</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bastug, Yavuz</creatorcontrib><creatorcontrib>Tokuc, Emre</creatorcontrib><creatorcontrib>Bastug, Nesrin</creatorcontrib><creatorcontrib>Artuk, Ilker</creatorcontrib><creatorcontrib>Tosun, Cagatay</creatorcontrib><creatorcontrib>Cakiroglu, Halime Sena</creatorcontrib><creatorcontrib>Aykan, Serdar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bastug, Yavuz</au><au>Tokuc, Emre</au><au>Bastug, Nesrin</au><au>Artuk, Ilker</au><au>Tosun, Cagatay</au><au>Cakiroglu, Halime Sena</au><au>Aykan, Serdar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2022-07</date><risdate>2022</risdate><volume>54</volume><issue>6</issue><spage>e14419</spage><epage>n/a</epage><pages>e14419-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>The aim of this study is to evaluate the value of the haematologic inflammatory parameters in predicting sperm retrieval rates during microdissection testicular sperm extraction (micro‐TESE).159 patients diagnosed with non‐obstructive azoospermia were included in the study. After excluding the patients that do not fit the inclusion criteria, age, smoking status, body‐mass index, serum luteinizing hormone, follicle‐stimulating hormone, total testosterone levels and neutrophil, lymphocyte and platelet counts were recorded. Neutrophil‐lymphocyte ratio, platelet‐lymphocyte ratio and systemic immune‐inflammation index were calculated. The primary outcome was defined as the presence of spermatozoa during the procedure and the association between the candidate predictors and primary endpoint were evaluated by logistic regression analysis. Then, a baseline model from age, smoking, body‐mass index and hormonal levels was built. Ratios and indexes were included, respectively, and were compared by multivariate analyses. Each of all three parameters was an independent predictor of obtaining spermatozoa during micro‐TESE procedure (all p < 0.001). Even though all three parameters were significant, neutrophil‐lymphocyte ratio and systemic immune‐inflammation index stood out as more powerful than platelet‐lymphocyte ratio (p < 0.08, p < 0.08 respectively). Additionally, adding these parameters individually to the baseline model significantly empowered the predictive value (all p < 0.001). Using haematologic inflammatory parameters in the prediction of sperm presence during microdissection testicular sperm extraction may be helpful when consulting the patient with having a better foresight of the procedural outcomes.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35266170</pmid><doi>10.1111/and.14419</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8221-8158</orcidid><orcidid>https://orcid.org/0000-0002-7889-4943</orcidid><orcidid>https://orcid.org/0000-0002-5885-9278</orcidid><orcidid>https://orcid.org/0000-0001-8963-6811</orcidid><orcidid>https://orcid.org/0000-0002-9256-940X</orcidid><orcidid>https://orcid.org/0000-0002-2341-2230</orcidid><orcidid>https://orcid.org/0000-0003-4879-7947</orcidid></addata></record> |
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| ispartof | Andrologia, 2022-07, Vol.54 (6), p.e14419-n/a |
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| subjects | Azoospermia Humans Inflammation inflammatory markers Leukocytes (neutrophilic) Luteinizing hormone Lymphocytes Male Microdissection - methods microdissection testicular sperm extraction Neutrophils Platelets prediction model Retrospective Studies Smoking Sperm Sperm Retrieval Spermatozoa Testes Testis - surgery Testosterone |
| title | Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction |
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