Thyroid Hormone Disruption by Organophosphate Esters Is Mediated by Nuclear/Membrane Thyroid Hormone Receptors: In Vitro, In Vivo, and In Silico Studies

Earlier mechanistic studies of many prohibited flame retardants (FRs) highlighted their thyroid hormone-disrupting activity through nuclear thyroid hormone receptors (nTRs), whereas some alternative FRs such as organophosphate esters (OPEs) exerted weak nTR-disrupting effects. However, an increasing...

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Veröffentlicht in:	Environmental science & technology 2022-04, Vol.56 (7), p.4241-4250
Hauptverfasser:	Li, Jian, Xu, Ying, Li, Na, Zuo, Rui, Zhai, Yuanzheng, Chen, Haiyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals China Disruption Ecotoxicology and Public Health Embryogenesis Embryonic growth stage Environmental Monitoring Esters Flame retardants Flame Retardants - analysis In vivo methods and tests Membranes Molecular docking Molecular Docking Simulation Organophosphates Protein interaction Proteins Proteomics Receptors Receptors, Thyroid Hormone Thyroid Thyroid gland Thyroid hormone receptors Thyroid Hormones Zebrafish
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