Single‐Cell Quantification of a Highly Biocompatible Dinuclear Iridium(III) Complex for Photocatalytic Cancer Therapy

Quantifying the content of metal‐based anticancer drugs within single cancer cells remains a challenge. Here, we used single‐cell inductively coupled plasma mass spectrometry to study the uptake and retention of mononuclear (Ir1) and dinuclear (Ir2) IrIII photoredox catalysts. This method allowed ra...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-06, Vol.61 (23), p.e202202098-n/a
Hauptverfasser:	Fan, Zhongxian, Rong, Yi, Sadhukhan, Tumpa, Liang, Shaoxia, Li, Wenqing, Yuan, Zhanxiang, Zhu, Zilin, Guo, Shunwen, Ji, Shaomin, Wang, Jinquan, Kushwaha, Rajesh, Banerjee, Samya, Raghavachari, Krishnan, Huang, Huaiyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic drugs Antitumor agents Biocompatibility Cancer Cancer therapies Catalysts Chemotherapy Inductively coupled plasma mass spectrometry Iridium Iridium Complexes Iridium compounds Mass spectrometry Mass spectroscopy NAD Oxidation Photocatalysis Photodynamic Therapy Photooxidation Photoredox catalysis Single-Cell ICP-MS Synergism Toxicity Tumors
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